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- W2113704273 abstract "Alterations of the hormonal environment may affect the risk of developing breast cancer in carriers of BRCA1 and BRCA2 germline mutations. Oral contraceptive use therefore increases risk, whereas smoking, through a possible antioestrogenic effect, decreases risk. 1 Brunet S-G Ghadirian P Rebbeck TR et al. Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. J Natl Cancer Inst. 1998; 90: 761-766 Crossref PubMed Scopus (116) Google Scholar In studies on mice, BRCA1 mRNA concentrations rise in pregnancy in association with epithelial proliferation and stay raised during pregnancy. 2 Marquis ST Rajan JV Wynshaw Boris A et al. The developmental pattern ofBRCA1 expression implies a role in differentiation of the breast and other tissues. Nat Genet. 1995; 11: 17-26 Crossref PubMed Scopus (330) Google Scholar Furthermore, the BRCA1 region and its promotor region contain hormone-receptor binding sites and combined treatment with 17β-oestradiol and progesterone has been shown to increase BRCA1 mRNA concentrations, although some studies suggest that this effect is indirect. 3 Marks JR Huper G Vaughan JP et al. BRCA1 expression is not directly responsive to estrogen. Oncogene. 1997; 14: 115-121 Crossref PubMed Scopus (104) Google Scholar In addition, breast cancer in female carriers of BRCA1 is commonly associated with features frequently found in pregnancy-associated breast cancer, such as tumours more likely to be oestrogen-receptor and progesterone-receptor negative. We therefore studied whether pregnancy might influence the risk of developing breast cancer in BRCA1 and BRCA2 mutation carriers." @default.
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- W2113704273 date "1998-10-01" @default.
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- W2113704273 title "Pregnancy-associated breast cancer in BRCA1 and BRCA2 germline mutation carriers" @default.
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- W2113704273 doi "https://doi.org/10.1016/s0140-6736(05)60750-7" @default.
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