FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113706105> ?p ?o ?g. }

• W2113706105 endingPage "685" @default.
• W2113706105 startingPage "677" @default.
• W2113706105 abstract "Leptin is a hormone that plays an important role in overall body energy homeostasis, and the obesity receptor, OB-R, is widely distributed in the organism. In the intestine, a multitude of leptin actions have been reported, but it is currently unclear to what extent the hormone affects the intestinal epithelial cells by an endocrine or exocrine signaling pathway. To elucidate this, the localization of endogenous porcine leptin and OB-R in enterocytes and colonocytes was studied. By immunofluorescence microscopy, both leptin and OB-R were mainly observed in the basolateral membrane of enterocytes and colonocytes but also in the apical microvillar membrane of the cells. By electron microscopy, coclustering of hormone and receptor in the plasma membrane and localization in endosomes was frequently detected at the basolateral surface of the epithelial cells, indicative of leptin signaling activity. In contrast, coclustering occurred less frequently at the apical cell surface, and subapical endosomal localization was hardly detectable. We conclude that leptin action in intestinal epithelial cells takes place at the basolateral plasma membrane, indicating that the hormone uses an endocrine pathway both in the jejunum and colon. In contrast, the data obtained did not provide evidence for an exocrine, lumenal action of the hormone in the intestine." @default.
• W2113706105 created "2016-06-24" @default.
• W2113706105 creator A5008019188 @default.
• W2113706105 creator A5043403243 @default.
• W2113706105 creator A5050655391 @default.
• W2113706105 date "2008-04-14" @default.
• W2113706105 modified "2023-10-12" @default.
• W2113706105 title "Leptin and the Obesity Receptor (OB-R) in the Small Intestine and Colon: A Colocalization Study" @default.
• W2113706105 cites W1502152603 @default.
• W2113706105 cites W1516728464 @default.
• W2113706105 cites W1523751054 @default.
• W2113706105 cites W1551216731 @default.
• W2113706105 cites W1804060812 @default.
• W2113706105 cites W1964815717 @default.
• W2113706105 cites W1970727986 @default.
• W2113706105 cites W1985111087 @default.
• W2113706105 cites W1991441340 @default.
• W2113706105 cites W1996713062 @default.
• W2113706105 cites W2007465428 @default.
• W2113706105 cites W2008103801 @default.
• W2113706105 cites W2009265787 @default.
• W2113706105 cites W2013552606 @default.
• W2113706105 cites W2017339165 @default.
• W2113706105 cites W2049118075 @default.
• W2113706105 cites W2063849708 @default.
• W2113706105 cites W2070190142 @default.
• W2113706105 cites W2072367079 @default.
• W2113706105 cites W2072598665 @default.
• W2113706105 cites W2077721010 @default.
• W2113706105 cites W2087568656 @default.
• W2113706105 cites W2097460048 @default.
• W2113706105 cites W2100837269 @default.
• W2113706105 cites W2101921785 @default.
• W2113706105 cites W2105987351 @default.
• W2113706105 cites W2120455859 @default.
• W2113706105 cites W2121936687 @default.
• W2113706105 cites W2123903846 @default.
• W2113706105 cites W2128400594 @default.
• W2113706105 cites W2133388060 @default.
• W2113706105 cites W2134708980 @default.
• W2113706105 cites W2135332398 @default.
• W2113706105 cites W2142329589 @default.
• W2113706105 cites W2152728566 @default.
• W2113706105 cites W2159329094 @default.
• W2113706105 cites W2160447553 @default.
• W2113706105 cites W2165545324 @default.
• W2113706105 cites W2195169201 @default.
• W2113706105 cites W4205370185 @default.
• W2113706105 cites W4212849655 @default.
• W2113706105 cites W4247302633 @default.
• W2113706105 doi "https://doi.org/10.1369/jhc.2008.950782" @default.
• W2113706105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2430163" @default.
• W2113706105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18413648" @default.
• W2113706105 hasPublicationYear "2008" @default.
• W2113706105 type Work @default.
• W2113706105 sameAs 2113706105 @default.
• W2113706105 citedByCount "21" @default.
• W2113706105 countsByYear W21137061052012 @default.
• W2113706105 countsByYear W21137061052013 @default.
• W2113706105 countsByYear W21137061052014 @default.
• W2113706105 countsByYear W21137061052015 @default.
• W2113706105 countsByYear W21137061052016 @default.
• W2113706105 countsByYear W21137061052017 @default.
• W2113706105 countsByYear W21137061052019 @default.
• W2113706105 countsByYear W21137061052020 @default.
• W2113706105 countsByYear W21137061052022 @default.
• W2113706105 crossrefType "journal-article" @default.
• W2113706105 hasAuthorship W2113706105A5008019188 @default.
• W2113706105 hasAuthorship W2113706105A5043403243 @default.
• W2113706105 hasAuthorship W2113706105A5050655391 @default.
• W2113706105 hasBestOaLocation W21137061051 @default.
• W2113706105 hasConcept C102747710 @default.
• W2113706105 hasConcept C103395026 @default.
• W2113706105 hasConcept C126322002 @default.
• W2113706105 hasConcept C134018914 @default.
• W2113706105 hasConcept C14372207 @default.
• W2113706105 hasConcept C1491633281 @default.
• W2113706105 hasConcept C170493617 @default.
• W2113706105 hasConcept C185592680 @default.
• W2113706105 hasConcept C2491326 @default.
• W2113706105 hasConcept C2780613262 @default.
• W2113706105 hasConcept C2781077229 @default.
• W2113706105 hasConcept C39587587 @default.
• W2113706105 hasConcept C40209533 @default.
• W2113706105 hasConcept C46699223 @default.
• W2113706105 hasConcept C511355011 @default.
• W2113706105 hasConcept C529295009 @default.
• W2113706105 hasConcept C54355233 @default.
• W2113706105 hasConcept C55493867 @default.
• W2113706105 hasConcept C71315377 @default.
• W2113706105 hasConcept C71924100 @default.
• W2113706105 hasConcept C86803240 @default.
• W2113706105 hasConcept C95444343 @default.
• W2113706105 hasConceptScore W2113706105C102747710 @default.
• W2113706105 hasConceptScore W2113706105C103395026 @default.
• W2113706105 hasConceptScore W2113706105C126322002 @default.
• W2113706105 hasConceptScore W2113706105C134018914 @default.
• W2113706105 hasConceptScore W2113706105C14372207 @default.

• next