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• W2113707064 abstract "Abstract IFN regulatory factor-3 is a transcription factor that is required for the rapid induction of type I IFNs in the innate antiviral response. Two noncanonical IκB kinase (IKK) family members, IKKε and TRAF family-associated NF-κB activator-binding kinase-1, have been shown to phosphorylate IFN regulatory factor-3 and are critically involved in virus-triggered and TLR3-mediated signaling leading to induction of type I IFNs. In yeast two-hybrid screens for potential IKKε-interacting proteins, we identified Ret finger protein (RFP) as an IKKε-interacting protein. Coimmunoprecipitation experiments indicated that RFP interacted with IKKε and TRAF family-associated NF-κB activator-binding kinase-1 as well as the two canonical IKK family members, IKKβ and IKKα. RFP inhibited activation of the IFN-stimulated response element and/or NF-κB mediated by the IKK family members and triggered by TNF, IL-1, polyinosinic-polycytidylic acid (ligand for TLR3), and viral infection. Moreover, knockdown of RFP expression by RNA interference-enhanced activation of IFN-stimulated response element and/or NF-κB triggered by polyinosinic-polycytidylic acid, TNF, and IL-1. Taken together, our findings suggest that RFP negatively regulates signaling involved in the antiviral response and inflammation by targeting the IKKs." @default.
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• W2113707064 date "2006-01-15" @default.
• W2113707064 modified "2023-10-03" @default.
• W2113707064 title "The Ret Finger Protein Inhibits Signaling Mediated by the Noncanonical and Canonical IκB Kinase Family Members" @default.
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• W2113707064 doi "https://doi.org/10.4049/jimmunol.176.2.1072" @default.
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