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- W2113707167 abstract "MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their cognate mRNA targets. ZFHX1B is a transcriptional repressor involved in the TGFβ signaling pathway and in processes of epithelial to mesenchymal transition via regulation of E-cadherin. We show that Zfhx1b and miR-200b are regionally coexpressed in the adult mouse brain and that miR-200b represses the expression of Zfhx1b via multiple sequence elements present in the 3′-untranslated region. Overexpression of miR-200b leads to repression of endogenous ZFHX1B, and inhibition of miR-200b relieves the repression of ZFHX1B. In accordance with these findings, miR-200b regulates the activity of the E-cadherin promoter." @default.
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- W2113707167 date "2007-06-21" @default.
- W2113707167 modified "2023-10-14" @default.
- W2113707167 title "miR-200b mediates post-transcriptional repression of ZFHX1B" @default.
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- W2113707167 doi "https://doi.org/10.1261/rna.586807" @default.
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