FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113721007> ?p ?o ?g. }

• W2113721007 endingPage "0" @default.
• W2113721007 startingPage "1075" @default.
• W2113721007 abstract "To better understand the relationship between the chemical structure and biological fate of dietary polyphenols, the hepatic metabolic stability and intestinal absorption of methylated polyphenols, in comparison with unmethylated polyphenols, were investigated in pooled human liver S9 fraction and human colon adenocarcinoma (Caco-2) cells. Consistent with previous in vivo studies, the two well known unmethylated polyphenols resveratrol (3,5,4′-trihydroxystilbene) and quercetin (3,5,7,3′,4′-pentahydroxyflavone) were rapidly eliminated by the S9 fraction in the presence of the appropriate cofactors for conjugation and oxidation. In contrast, the methylated flavones, i.e., 7-methoxyflavone, 7,4′-dimethoxyflavone, 5,7-dimethoxyflavone, and 5,7,4′-trimethoxyflavone, were relatively stable, indicating high resistance to hepatic metabolism. The corresponding unmethylated flavones, i.e., 7-hydroxyflavone, 7,4′-dihydroxyflavone, chrysin (5,7-dihydroxyflavone), and apigenin (5,7,4′-trihydroxyflavone), were rapidly eliminated because of extensive glucuronidation and/or sulfation just as resveratrol and quercetin were. The rate of intestinal absorption was evaluated using Caco-2 cells grown in porous inserts. The methylated flavones showed approximately 5- to 8-fold higher apparent permeability (<i>P</i>_app, 22.6–27.6 × 10^–6 cm s^–1) of apical to basolateral flux than the unmethylated flavones (<i>P</i>_app, 3.0–7.8 × 10^–6 cm s^–1). The lower <i>P</i>_app values for the unmethylated flavones correlated with their extensive metabolism in the Caco-2 cells. Thus, combined use of the hepatic S9 fraction and Caco-2 cells will be useful for predicting the oral bioavailability of dietary polyphenols. The higher hepatic metabolic stability and intestinal absorption of the methylated polyphenols make them more favorable than the unmethylated polyphenols to be developed as potential cancer chemopreventive agents." @default.
• W2113721007 created "2016-06-24" @default.
• W2113721007 creator A5039575175 @default.
• W2113721007 creator A5058685058 @default.
• W2113721007 creator A5084501306 @default.
• W2113721007 date "2003-11-08" @default.
• W2113721007 modified "2023-10-15" @default.
• W2113721007 title "Use of injections in healthcare settings worldwide, 2000: literature review and regional estimates" @default.
• W2113721007 cites W1491551588 @default.
• W2113721007 cites W1726263683 @default.
• W2113721007 cites W1967944571 @default.
• W2113721007 cites W1979179908 @default.
• W2113721007 cites W1987080862 @default.
• W2113721007 cites W1987172912 @default.
• W2113721007 cites W2005802158 @default.
• W2113721007 cites W2014151208 @default.
• W2113721007 cites W2016812287 @default.
• W2113721007 cites W2031313735 @default.
• W2113721007 cites W2035179461 @default.
• W2113721007 cites W2038967439 @default.
• W2113721007 cites W2052405917 @default.
• W2113721007 cites W2099456167 @default.
• W2113721007 cites W2101997013 @default.
• W2113721007 cites W2121960580 @default.
• W2113721007 cites W2122536157 @default.
• W2113721007 cites W2125649354 @default.
• W2113721007 cites W2127724275 @default.
• W2113721007 cites W2144079615 @default.
• W2113721007 cites W2164806154 @default.
• W2113721007 cites W2185560519 @default.
• W2113721007 cites W2210585230 @default.
• W2113721007 cites W2395472482 @default.
• W2113721007 cites W4298039624 @default.
• W2113721007 cites W4300992659 @default.
• W2113721007 cites W4302359357 @default.
• W2113721007 doi "https://doi.org/10.1136/bmj.327.7423.1075" @default.
• W2113721007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/261740" @default.
• W2113721007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14604927" @default.
• W2113721007 hasPublicationYear "2003" @default.
• W2113721007 type Work @default.
• W2113721007 sameAs 2113721007 @default.
• W2113721007 citedByCount "272" @default.
• W2113721007 countsByYear W21137210072012 @default.
• W2113721007 countsByYear W21137210072013 @default.
• W2113721007 countsByYear W21137210072014 @default.
• W2113721007 countsByYear W21137210072015 @default.
• W2113721007 countsByYear W21137210072016 @default.
• W2113721007 countsByYear W21137210072017 @default.
• W2113721007 countsByYear W21137210072018 @default.
• W2113721007 countsByYear W21137210072019 @default.
• W2113721007 countsByYear W21137210072020 @default.
• W2113721007 countsByYear W21137210072021 @default.
• W2113721007 countsByYear W21137210072022 @default.
• W2113721007 countsByYear W21137210072023 @default.
• W2113721007 crossrefType "journal-article" @default.
• W2113721007 hasAuthorship W2113721007A5039575175 @default.
• W2113721007 hasAuthorship W2113721007A5058685058 @default.
• W2113721007 hasAuthorship W2113721007A5084501306 @default.
• W2113721007 hasBestOaLocation W21137210071 @default.
• W2113721007 hasConcept C185592680 @default.
• W2113721007 hasConcept C202751555 @default.
• W2113721007 hasConcept C2776292868 @default.
• W2113721007 hasConcept C2776816829 @default.
• W2113721007 hasConcept C2778004101 @default.
• W2113721007 hasConcept C2778609962 @default.
• W2113721007 hasConcept C2779054382 @default.
• W2113721007 hasConcept C2779478871 @default.
• W2113721007 hasConcept C2779907587 @default.
• W2113721007 hasConcept C2781263971 @default.
• W2113721007 hasConcept C43617362 @default.
• W2113721007 hasConcept C55493867 @default.
• W2113721007 hasConcept C70899900 @default.
• W2113721007 hasConcept C71240020 @default.
• W2113721007 hasConcept C87644729 @default.
• W2113721007 hasConceptScore W2113721007C185592680 @default.
• W2113721007 hasConceptScore W2113721007C202751555 @default.
• W2113721007 hasConceptScore W2113721007C2776292868 @default.
• W2113721007 hasConceptScore W2113721007C2776816829 @default.
• W2113721007 hasConceptScore W2113721007C2778004101 @default.
• W2113721007 hasConceptScore W2113721007C2778609962 @default.
• W2113721007 hasConceptScore W2113721007C2779054382 @default.
• W2113721007 hasConceptScore W2113721007C2779478871 @default.
• W2113721007 hasConceptScore W2113721007C2779907587 @default.
• W2113721007 hasConceptScore W2113721007C2781263971 @default.
• W2113721007 hasConceptScore W2113721007C43617362 @default.
• W2113721007 hasConceptScore W2113721007C55493867 @default.
• W2113721007 hasConceptScore W2113721007C70899900 @default.
• W2113721007 hasConceptScore W2113721007C71240020 @default.
• W2113721007 hasConceptScore W2113721007C87644729 @default.
• W2113721007 hasIssue "7423" @default.
• W2113721007 hasLocation W21137210071 @default.
• W2113721007 hasLocation W21137210072 @default.
• W2113721007 hasLocation W21137210073 @default.
• W2113721007 hasLocation W21137210074 @default.
• W2113721007 hasOpenAccess W2113721007 @default.
• W2113721007 hasPrimaryLocation W21137210071 @default.
• W2113721007 hasRelatedWork W1982675389 @default.
• W2113721007 hasRelatedWork W1983176181 @default.

• next