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• W2113722701 abstract "Dysregulated innate responses, particularly excessive activation of interferon (IFN) pathways, have been implicated in the development of autoimmune pathologies. Autoreactivity frequently targets IFN-inducible genes such as the Ro autoantigens, which ubiquitinate and inhibit interferon regulatory factors (IRFs). A new study validates the role of these common autoantigens in preventing autoimmunity. The findings reveal that injury-induced systemic autoimmune disease is exacerbated in the absence of Ro52/Trim21 and is driven by the IL-23-Th17 pathway." @default.
• W2113722701 created "2016-06-24" @default.
• W2113722701 creator A5004889712 @default.
• W2113722701 creator A5016713616 @default.
• W2113722701 date "2009-07-27" @default.
• W2113722701 modified "2023-10-18" @default.
• W2113722701 title "Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice" @default.
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• W2113722701 doi "https://doi.org/10.1084/jem.20091507" @default.
• W2113722701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2722177" @default.
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