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• W2113743998 abstract "With the advent of magnetic resonance imaging (MRI) it has become apparent that paramagnetic contrast agents may have a place in clinical practice. The mechanism of action, development, techniques of use and initial animal and clinical results are reviewed. Gadolinium diethylene triamine penta acetic acid (Gd3+-DTPA) has proved an effective paramagnetic contrast agent in experimental animals and clinical trials with this agent commenced in November–December 1983. Gd3+-DTPA will cross a damaged blood-brain barrier, is excreted mainly by glomerular filtration and is distributed mainly in the extracellular space. No short-term toxicity has been detected. Long-term toxicity is, as yet, unknown. Optimum dose, pulse sequences and timing of imaging remain to be determined by further studies but Gd3+-DTPA shows promise as a useful addition to MRI. With the advent of magnetic resonance imaging (MRI) it has become apparent that paramagnetic contrast agents may have a place in clinical practice. The mechanism of action, development, techniques of use and initial animal and clinical results are reviewed. Gadolinium diethylene triamine penta acetic acid (Gd3+-DTPA) has proved an effective paramagnetic contrast agent in experimental animals and clinical trials with this agent commenced in November–December 1983. Gd3+-DTPA will cross a damaged blood-brain barrier, is excreted mainly by glomerular filtration and is distributed mainly in the extracellular space. No short-term toxicity has been detected. Long-term toxicity is, as yet, unknown. Optimum dose, pulse sequences and timing of imaging remain to be determined by further studies but Gd3+-DTPA shows promise as a useful addition to MRI." @default.
• W2113743998 created "2016-06-24" @default.
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• W2113743998 date "1985-01-01" @default.
• W2113743998 modified "2023-09-26" @default.
• W2113743998 title "Contrast agents in magnetic resonance imaging" @default.
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• W2113743998 doi "https://doi.org/10.1016/s0009-9260(85)80234-8" @default.
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