Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113744229> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2113744229 endingPage "G362" @default.
- W2113744229 startingPage "G355" @default.
- W2113744229 abstract "The hypothesis that Kupffer cells and infiltrating neutrophils generate reactive oxygen in the hepatic sinusoids and may contribute to ischemia-reperfusion injury in the liver was investigated in a model of partial no-flow ischemia and reperfusion in male Fischer rats in vivo. During the reperfusion period of 60 min, plasma concentrations of glutathione disulfide (GSSG; index of oxidant stress) increased from 1.62 +/- 0.20 microM glutathione (GSH) equivalents to maximal values of 11.82 +/- 1.45 (45 min ischemia), 24.19 +/- 2.35 (60 min ischemia), and 70.20 +/- 7.8 (120 min ischemia). The basal tissue GSSG content in the postischemic lobes (0.19 +/- 0.02 nmol GSH eq/mg protein) increased by 50-100%. Although the number of neutrophils in liver and lung increased by 3- to 10-fold during reperfusion, there was no positive correlation between the number of neutrophils and the GSSG concentrations measured in plasma or tissue. However, activation of Kupffer cells with high doses of retinol or with Propionibacterium acnes significantly enhanced plasma GSSG levels, while inactivation of Kupffer cells with methyl palmitate or gadolinium chloride significantly attenuated the increase of plasma GSSG. Inactivation of Kupffer cells protected the liver significantly against ischemia-reperfusion injury. It is concluded that Kupffer cells are the predominant source of reactive oxygen formed during the initial reperfusion period and that Kupffer cell activity (including reactive oxygen formation) contributes to reperfusion injury in the liver in vivo." @default.
- W2113744229 created "2016-06-24" @default.
- W2113744229 creator A5043513654 @default.
- W2113744229 creator A5087156903 @default.
- W2113744229 date "1991-03-01" @default.
- W2113744229 modified "2023-09-30" @default.
- W2113744229 title "Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver" @default.
- W2113744229 cites W1492558638 @default.
- W2113744229 cites W1522676079 @default.
- W2113744229 cites W1574945736 @default.
- W2113744229 cites W1717897856 @default.
- W2113744229 cites W1967596935 @default.
- W2113744229 cites W1971307209 @default.
- W2113744229 cites W1973536579 @default.
- W2113744229 cites W1975169344 @default.
- W2113744229 cites W2010635224 @default.
- W2113744229 cites W2032821562 @default.
- W2113744229 cites W2047643353 @default.
- W2113744229 cites W2048828974 @default.
- W2113744229 cites W2050069116 @default.
- W2113744229 cites W2056129425 @default.
- W2113744229 cites W2077719038 @default.
- W2113744229 cites W2107228070 @default.
- W2113744229 cites W2148879813 @default.
- W2113744229 cites W2172336930 @default.
- W2113744229 cites W2183104817 @default.
- W2113744229 cites W2200674871 @default.
- W2113744229 cites W2338119022 @default.
- W2113744229 cites W2339877196 @default.
- W2113744229 cites W2395196403 @default.
- W2113744229 cites W2414606354 @default.
- W2113744229 cites W2415285497 @default.
- W2113744229 cites W2426584680 @default.
- W2113744229 doi "https://doi.org/10.1152/ajpgi.1991.260.3.g355" @default.
- W2113744229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2003603" @default.
- W2113744229 hasPublicationYear "1991" @default.
- W2113744229 type Work @default.
- W2113744229 sameAs 2113744229 @default.
- W2113744229 citedByCount "258" @default.
- W2113744229 countsByYear W21137442292012 @default.
- W2113744229 countsByYear W21137442292013 @default.
- W2113744229 countsByYear W21137442292014 @default.
- W2113744229 countsByYear W21137442292015 @default.
- W2113744229 countsByYear W21137442292016 @default.
- W2113744229 countsByYear W21137442292017 @default.
- W2113744229 countsByYear W21137442292018 @default.
- W2113744229 countsByYear W21137442292019 @default.
- W2113744229 countsByYear W21137442292020 @default.
- W2113744229 countsByYear W21137442292021 @default.
- W2113744229 countsByYear W21137442292022 @default.
- W2113744229 countsByYear W21137442292023 @default.
- W2113744229 crossrefType "journal-article" @default.
- W2113744229 hasAuthorship W2113744229A5043513654 @default.
- W2113744229 hasAuthorship W2113744229A5087156903 @default.
- W2113744229 hasConcept C126322002 @default.
- W2113744229 hasConcept C134018914 @default.
- W2113744229 hasConcept C181199279 @default.
- W2113744229 hasConcept C185592680 @default.
- W2113744229 hasConcept C2778904781 @default.
- W2113744229 hasConcept C2779179908 @default.
- W2113744229 hasConcept C2780114680 @default.
- W2113744229 hasConcept C48349386 @default.
- W2113744229 hasConcept C538909803 @default.
- W2113744229 hasConcept C541997718 @default.
- W2113744229 hasConcept C55493867 @default.
- W2113744229 hasConcept C71924100 @default.
- W2113744229 hasConceptScore W2113744229C126322002 @default.
- W2113744229 hasConceptScore W2113744229C134018914 @default.
- W2113744229 hasConceptScore W2113744229C181199279 @default.
- W2113744229 hasConceptScore W2113744229C185592680 @default.
- W2113744229 hasConceptScore W2113744229C2778904781 @default.
- W2113744229 hasConceptScore W2113744229C2779179908 @default.
- W2113744229 hasConceptScore W2113744229C2780114680 @default.
- W2113744229 hasConceptScore W2113744229C48349386 @default.
- W2113744229 hasConceptScore W2113744229C538909803 @default.
- W2113744229 hasConceptScore W2113744229C541997718 @default.
- W2113744229 hasConceptScore W2113744229C55493867 @default.
- W2113744229 hasConceptScore W2113744229C71924100 @default.
- W2113744229 hasIssue "3" @default.
- W2113744229 hasLocation W21137442291 @default.
- W2113744229 hasLocation W21137442292 @default.
- W2113744229 hasOpenAccess W2113744229 @default.
- W2113744229 hasPrimaryLocation W21137442291 @default.
- W2113744229 hasRelatedWork W1944912191 @default.
- W2113744229 hasRelatedWork W1964911738 @default.
- W2113744229 hasRelatedWork W1974805526 @default.
- W2113744229 hasRelatedWork W1983855325 @default.
- W2113744229 hasRelatedWork W2023252159 @default.
- W2113744229 hasRelatedWork W2062369384 @default.
- W2113744229 hasRelatedWork W2071349074 @default.
- W2113744229 hasRelatedWork W2124941067 @default.
- W2113744229 hasRelatedWork W2415509219 @default.
- W2113744229 hasRelatedWork W2418350788 @default.
- W2113744229 hasVolume "260" @default.
- W2113744229 isParatext "false" @default.
- W2113744229 isRetracted "false" @default.
- W2113744229 magId "2113744229" @default.
- W2113744229 workType "article" @default.