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- W2113752148 endingPage "50" @default.
- W2113752148 startingPage "43" @default.
- W2113752148 abstract "Gastric cancer (GC) is one of the commonest cancers with high mortality. Despite improvement in early detection and treatments, the outcome of advanced GC remains unsatisfactory due to the poor understanding of the intricate pathogenesis of GC. GC is a multifactorial and multistep disease which involves activation of oncogenes and inactivation of tumor suppressor genes. Ubiquitin proteasome system (UPS) catalyzing many critical protein substrates is involved in initiation and development of cancer. F-box proteins (FBPs) are the main functional components of UPS. Accumulated evidence strongly suggests that abnormal regulations of FBPs contribute to uncontrolled proliferation, genomic instability and cancer. In this review, we discuss how the dysregulated FBPs promote the occurrence and development of GC." @default.
- W2113752148 created "2016-06-24" @default.
- W2113752148 creator A5015531883 @default.
- W2113752148 creator A5023531951 @default.
- W2113752148 creator A5053056041 @default.
- W2113752148 creator A5053661871 @default.
- W2113752148 date "2015-05-04" @default.
- W2113752148 modified "2023-10-16" @default.
- W2113752148 title "Function and mechanism of F-box proteins in gastric cancer (Review)" @default.
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- W2113752148 doi "https://doi.org/10.3892/ijo.2015.2983" @default.
- W2113752148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25955829" @default.
- W2113752148 hasPublicationYear "2015" @default.