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- W2113753611 abstract "We have recently shown that the FP(B) prostanoid receptor activates beta-catenin signaling through the activation of Rho in human embryo kidney (HEK)-293 cells stably expressing the FP(B) receptors. We now report that the FP(B) receptor can stimulate cyclooxygenase-2 promoter activity and may, therefore, regulate the expression of cyclooxygenase-2. This stimulation of cyclooxygenase-2 promoter activity is blocked by pretreatment with an inhibitor of Rho, but not with an inhibitor of protein kinase C (PKC). Potential up regulation of cyclooxygenase-2 expression by the FP(B) receptor would establish a positive feedback loop that would drive beta-catenin signaling and could be involved in cancer." @default.
- W2113753611 created "2016-06-24" @default.
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- W2113753611 date "2003-03-01" @default.
- W2113753611 modified "2023-10-18" @default.
- W2113753611 title "Prostaglandin F2α stimulation of cyclooxygenase-2 promoter activity by the FPB prostanoid receptor" @default.
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- W2113753611 doi "https://doi.org/10.1016/s0014-2999(03)01485-7" @default.
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