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• W2113755324 abstract "Recent studies strongly suggest that the gene expression sustaining both normal and pathogenic bacterial growth is governed by the structural dynamics of the chromosome. However, the mechanistic device coordinating the chromosomal configuration with selective expression of the adaptive traits remains largely unknown. We used a holistic approach exploring the inherent relationships between the physicochemical properties of the DNA and the expression of adaptive traits, including virulence factors, in the pathogen Dickeya dadantii (formerly Erwinia chrysanthemi). In the transcriptomes obtained under adverse conditions encountered during bacterial infection, we explored the patterns of chromosomal DNA sequence organization, supercoil dynamics, and gene expression densities, together with the long-range regulatory impacts of the abundant DNA architectural proteins implicated in pathogenicity control. By integrating these data, we identified transient chromosomal domains of coherent gene expression featuring distinct couplings between DNA thermodynamic stability, supercoil dynamics, and virulence traits.We infer that the organization of transient chromosomal domains serving specific functions acts as a fundamental device for versatile adjustment of the pathogen to environmental stress. We believe that the identification of chromosomal stress-response domains harboring distinct virulence traits and mediating the cellular adaptive behavior provides a breakthrough in understanding the control mechanisms of bacterial pathogenicity." @default.
• W2113755324 created "2016-06-24" @default.
• W2113755324 creator A5013121971 @default.
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• W2113755324 date "2015-07-01" @default.
• W2113755324 modified "2023-10-17" @default.
• W2113755324 title "Chromosomal “Stress-Response” Domains Govern the Spatiotemporal Expression of the Bacterial Virulence Program" @default.
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• W2113755324 doi "https://doi.org/10.1128/mbio.00353-15" @default.
• W2113755324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4436070" @default.
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• W2113755324 hasPublicationYear "2015" @default.
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