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• W2113755609 abstract "OBJECTIVE: To determine whether the period of ejaculatory abstinence (EA) influences the total antioxidant capacity (TAC) of semen or impacts lipid peroxidation (LPO) of sperm membranes, the latter a measure of reactive oxygen species damage.DESIGN: A prospective crossover trial.MATERIALS AND METHODS: Forty men of infertile couples undergoing IUI provided semen specimens after EA periods of 1 and 4 days. Semen analysis, peroxidase staining, and assays for TAC (TAS Randox kit with ABTS®) and LPO (lipid hydroperoxide assay) were performed. A sample size of 32 was calculated to have 80% power to detect a difference of 0.77 in TAC between the paired EA groups. Measures were compared between days 1 and 4 within individuals using paired t-tests.RESULTS: The shorter period of EA (1 day versus 4 days) resulted in significant decreases in semen volume (percentage change=-24%, p<0.002), sperm density (-3.2%, p=0.02), and total sperm count (-28.4%, p<0.002). There was a significant increase in TAC with the shorter period of EA (1 day) compared to 4 days of EA (p<0.02). There were no differences detected in sperm membrane LPO comparing 1 day of EA and 4 days of EA.CONCLUSION: A shorter period of EA (1 day) increases seminal total antioxidant capacity (TAC) compared to a longer period of EA (4 days). Despite a reduction in total sperm count seen with 1 day of EA (comfirmed in this study), our previous study showed that pregnancy rates after IUI with 1 day of EA are higher than longer periods of EA. Higher TAC levels from a shorter period of EA will reduce seminal oxidative stress and may be a mechanism for improving sperm quality and increasing pregnancy rates after IUI. There is no measurable difference in sperm membrane LPO comparing 1 day versus 4 days of EA. Higher TAC levels could diminish oxidative stress-induced sperm damage by mechanisms independent of LPO. OBJECTIVE: To determine whether the period of ejaculatory abstinence (EA) influences the total antioxidant capacity (TAC) of semen or impacts lipid peroxidation (LPO) of sperm membranes, the latter a measure of reactive oxygen species damage. DESIGN: A prospective crossover trial. MATERIALS AND METHODS: Forty men of infertile couples undergoing IUI provided semen specimens after EA periods of 1 and 4 days. Semen analysis, peroxidase staining, and assays for TAC (TAS Randox kit with ABTS®) and LPO (lipid hydroperoxide assay) were performed. A sample size of 32 was calculated to have 80% power to detect a difference of 0.77 in TAC between the paired EA groups. Measures were compared between days 1 and 4 within individuals using paired t-tests. RESULTS: The shorter period of EA (1 day versus 4 days) resulted in significant decreases in semen volume (percentage change=-24%, p<0.002), sperm density (-3.2%, p=0.02), and total sperm count (-28.4%, p<0.002). There was a significant increase in TAC with the shorter period of EA (1 day) compared to 4 days of EA (p<0.02). There were no differences detected in sperm membrane LPO comparing 1 day of EA and 4 days of EA. CONCLUSION: A shorter period of EA (1 day) increases seminal total antioxidant capacity (TAC) compared to a longer period of EA (4 days). Despite a reduction in total sperm count seen with 1 day of EA (comfirmed in this study), our previous study showed that pregnancy rates after IUI with 1 day of EA are higher than longer periods of EA. Higher TAC levels from a shorter period of EA will reduce seminal oxidative stress and may be a mechanism for improving sperm quality and increasing pregnancy rates after IUI. There is no measurable difference in sperm membrane LPO comparing 1 day versus 4 days of EA. Higher TAC levels could diminish oxidative stress-induced sperm damage by mechanisms independent of LPO." @default.
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• W2113755609 date "2010-09-01" @default.
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• W2113755609 title "The influence of ejaculatory abstinence on oxidative stress in semen: a mechanism that explains improved pregnancy outcomes after intrauterine insemination?" @default.
• W2113755609 doi "https://doi.org/10.1016/j.fertnstert.2010.07.582" @default.
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