FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113757314> ?p ?o ?g. }

• W2113757314 endingPage "1527" @default.
• W2113757314 startingPage "1522" @default.
• W2113757314 abstract "Objective: To describe a case of life-threatening flecainide intoxication in a toddler, secondary to accidental reversal of syringes used for oral administration. Case Summary: A 2-year-old male with a history of a persistent junctional reciprocating tachycardia had been receiving flecainide 4.8 mg/kg/day (1 mL 3 times daily) and nadolol 2 mg/kg/day (5 mL once daily) for 10 months. One morning, 3 hours after the drugs were administered, he became bradycardic (heart rate 50 beats/min) and then presented to the emergency department with vital signs absent. After initial cardiopulmonary resuscitation and epinephrine, he was bradycardic; this was followed by wide-complex tachycardia that converted rapidly to narrow-complex tachycardia after bolus administration of intravenous sodium bicarbonate for suspected flecainide intoxication. Following resuscitation, he remained hemodynamically stable and was discharged in normal sinus rhythm without neurologic sequelae. Drug concentrations obtained at the time of presentation showed a serum concentration of flecainide of 0.668 μg/mL. Drug formulations were also analyzed and found to contain the expected concentration of flecainide. Discussion: Literature regarding adverse drug events in the pediatric outpatient population is reviewed, as well as how these risks apply to flecainide, a medication with a low margin of safety. Pediatric experience with flecainide intoxication and sodium bicarbonate administration as an antidote is reviewed. Analysis of the serum drug concentrations demonstrated blood concentrations consistent with syringe reversal, which would have produced a 5-fold flecainide overdose. The Naranjo probability scale indicated a highly probable relationship between flecainide ingestion and the life-threatening event in this case. Conclusions: This case of life-threatening flecainide intoxication in a young child, secondary to accidental reversal of medication syringes, underscores the importance of providing parents with accurate dispensing information and labeling medication bottles and syringes in an unambiguous manner." @default.
• W2113757314 created "2016-06-24" @default.
• W2113757314 creator A5009787522 @default.
• W2113757314 creator A5029272828 @default.
• W2113757314 creator A5072342533 @default.
• W2113757314 creator A5073859471 @default.
• W2113757314 creator A5084898240 @default.
• W2113757314 date "2009-08-11" @default.
• W2113757314 modified "2023-09-23" @default.
• W2113757314 title "Life-Threatening Flecainide Intoxication in a Young Child Secondary to Medication Error" @default.
• W2113757314 cites W1875384069 @default.
• W2113757314 cites W1982552047 @default.
• W2113757314 cites W1995938985 @default.
• W2113757314 cites W2006562248 @default.
• W2113757314 cites W2032419234 @default.
• W2113757314 cites W2034174052 @default.
• W2113757314 cites W2043681979 @default.
• W2113757314 cites W2048779655 @default.
• W2113757314 cites W2062522218 @default.
• W2113757314 cites W2064076422 @default.
• W2113757314 cites W2064756908 @default.
• W2113757314 cites W2067978628 @default.
• W2113757314 cites W2070007182 @default.
• W2113757314 cites W2084942160 @default.
• W2113757314 cites W2085000573 @default.
• W2113757314 cites W2090896010 @default.
• W2113757314 cites W2110191867 @default.
• W2113757314 cites W2113254247 @default.
• W2113757314 cites W2150282986 @default.
• W2113757314 cites W4231945052 @default.
• W2113757314 doi "https://doi.org/10.1345/aph.1l549" @default.
• W2113757314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19671803" @default.
• W2113757314 hasPublicationYear "2009" @default.
• W2113757314 type Work @default.
• W2113757314 sameAs 2113757314 @default.
• W2113757314 citedByCount "23" @default.
• W2113757314 countsByYear W21137573142012 @default.
• W2113757314 countsByYear W21137573142013 @default.
• W2113757314 countsByYear W21137573142014 @default.
• W2113757314 countsByYear W21137573142015 @default.
• W2113757314 countsByYear W21137573142016 @default.
• W2113757314 countsByYear W21137573142017 @default.
• W2113757314 countsByYear W21137573142018 @default.
• W2113757314 countsByYear W21137573142020 @default.
• W2113757314 countsByYear W21137573142022 @default.
• W2113757314 crossrefType "journal-article" @default.
• W2113757314 hasAuthorship W2113757314A5009787522 @default.
• W2113757314 hasAuthorship W2113757314A5029272828 @default.
• W2113757314 hasAuthorship W2113757314A5072342533 @default.
• W2113757314 hasAuthorship W2113757314A5073859471 @default.
• W2113757314 hasAuthorship W2113757314A5084898240 @default.
• W2113757314 hasConcept C126322002 @default.
• W2113757314 hasConcept C147789679 @default.
• W2113757314 hasConcept C185592680 @default.
• W2113757314 hasConcept C194828623 @default.
• W2113757314 hasConcept C2776315796 @default.
• W2113757314 hasConcept C2776420369 @default.
• W2113757314 hasConcept C2777055891 @default.
• W2113757314 hasConcept C2777495988 @default.
• W2113757314 hasConcept C2777953023 @default.
• W2113757314 hasConcept C2778165595 @default.
• W2113757314 hasConcept C2779161974 @default.
• W2113757314 hasConcept C2779837460 @default.
• W2113757314 hasConcept C2780283014 @default.
• W2113757314 hasConcept C3017944768 @default.
• W2113757314 hasConcept C42219234 @default.
• W2113757314 hasConcept C43376680 @default.
• W2113757314 hasConcept C71924100 @default.
• W2113757314 hasConcept C84393581 @default.
• W2113757314 hasConceptScore W2113757314C126322002 @default.
• W2113757314 hasConceptScore W2113757314C147789679 @default.
• W2113757314 hasConceptScore W2113757314C185592680 @default.
• W2113757314 hasConceptScore W2113757314C194828623 @default.
• W2113757314 hasConceptScore W2113757314C2776315796 @default.
• W2113757314 hasConceptScore W2113757314C2776420369 @default.
• W2113757314 hasConceptScore W2113757314C2777055891 @default.
• W2113757314 hasConceptScore W2113757314C2777495988 @default.
• W2113757314 hasConceptScore W2113757314C2777953023 @default.
• W2113757314 hasConceptScore W2113757314C2778165595 @default.
• W2113757314 hasConceptScore W2113757314C2779161974 @default.
• W2113757314 hasConceptScore W2113757314C2779837460 @default.
• W2113757314 hasConceptScore W2113757314C2780283014 @default.
• W2113757314 hasConceptScore W2113757314C3017944768 @default.
• W2113757314 hasConceptScore W2113757314C42219234 @default.
• W2113757314 hasConceptScore W2113757314C43376680 @default.
• W2113757314 hasConceptScore W2113757314C71924100 @default.
• W2113757314 hasConceptScore W2113757314C84393581 @default.
• W2113757314 hasIssue "9" @default.
• W2113757314 hasLocation W21137573141 @default.
• W2113757314 hasLocation W21137573142 @default.
• W2113757314 hasOpenAccess W2113757314 @default.
• W2113757314 hasPrimaryLocation W21137573141 @default.
• W2113757314 hasRelatedWork W173463638 @default.
• W2113757314 hasRelatedWork W2073169453 @default.
• W2113757314 hasRelatedWork W2082123349 @default.
• W2113757314 hasRelatedWork W2084351430 @default.
• W2113757314 hasRelatedWork W2087220383 @default.
• W2113757314 hasRelatedWork W2187927279 @default.

• next