FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113759125> ?p ?o ?g. }

• W2113759125 endingPage "1046" @default.
• W2113759125 startingPage "1037" @default.
• W2113759125 abstract "X-ray crystallography has provided tremendous insight into the different structural states of membrane proteins and, in particular, of ion channels. However, the molecular forces that determine the thermodynamic stability of a particular state are poorly understood. Here we analyze the different X-ray structures of an inwardly rectifying potassium channel (Kir1.1) in relation to functional data we obtained for over 190 mutants in Kir1.1. This mutagenic perturbation analysis uncovered an extensive, state-dependent network of physically interacting residues that stabilizes the pre-open and open states of the channel, but fragments upon channel closure. We demonstrate that this gating network is an important structural determinant of the thermodynamic stability of these different gating states and determines the impact of individual mutations on channel function. These results have important implications for our understanding of not only K+ channel gating but also the more general nature of conformational transitions that occur in other allosteric proteins." @default.
• W2113759125 created "2016-06-24" @default.
• W2113759125 creator A5030564148 @default.
• W2113759125 creator A5033094392 @default.
• W2113759125 creator A5041718990 @default.
• W2113759125 creator A5053717161 @default.
• W2113759125 creator A5060755916 @default.
• W2113759125 creator A5066737605 @default.
• W2113759125 creator A5089871276 @default.
• W2113759125 date "2014-07-01" @default.
• W2113759125 modified "2023-10-11" @default.
• W2113759125 title "State-Dependent Network Connectivity Determines Gating in a K+ Channel" @default.
• W2113759125 cites W1518056784 @default.
• W2113759125 cites W161542459 @default.
• W2113759125 cites W1975419967 @default.
• W2113759125 cites W2007061409 @default.
• W2113759125 cites W2015233467 @default.
• W2113759125 cites W2016555254 @default.
• W2113759125 cites W2027792287 @default.
• W2113759125 cites W2029667189 @default.
• W2113759125 cites W2030310238 @default.
• W2113759125 cites W2032401689 @default.
• W2113759125 cites W2037244538 @default.
• W2113759125 cites W2048332551 @default.
• W2113759125 cites W2052193304 @default.
• W2113759125 cites W2065283382 @default.
• W2113759125 cites W2072820518 @default.
• W2113759125 cites W2076539459 @default.
• W2113759125 cites W2087496251 @default.
• W2113759125 cites W2090915207 @default.
• W2113759125 cites W2100097046 @default.
• W2113759125 cites W2100949334 @default.
• W2113759125 cites W2103770142 @default.
• W2113759125 cites W2104759180 @default.
• W2113759125 cites W2107208446 @default.
• W2113759125 cites W2123369578 @default.
• W2113759125 cites W2132358083 @default.
• W2113759125 cites W2138075253 @default.
• W2113759125 cites W2144257031 @default.
• W2113759125 cites W2161227647 @default.
• W2113759125 cites W2171190723 @default.
• W2113759125 cites W2177731497 @default.
• W2113759125 doi "https://doi.org/10.1016/j.str.2014.04.018" @default.
• W2113759125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4087272" @default.
• W2113759125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24980796" @default.
• W2113759125 hasPublicationYear "2014" @default.
• W2113759125 type Work @default.
• W2113759125 sameAs 2113759125 @default.
• W2113759125 citedByCount "8" @default.
• W2113759125 countsByYear W21137591252014 @default.
• W2113759125 countsByYear W21137591252015 @default.
• W2113759125 countsByYear W21137591252018 @default.
• W2113759125 countsByYear W21137591252020 @default.
• W2113759125 countsByYear W21137591252023 @default.
• W2113759125 crossrefType "journal-article" @default.
• W2113759125 hasAuthorship W2113759125A5030564148 @default.
• W2113759125 hasAuthorship W2113759125A5033094392 @default.
• W2113759125 hasAuthorship W2113759125A5041718990 @default.
• W2113759125 hasAuthorship W2113759125A5053717161 @default.
• W2113759125 hasAuthorship W2113759125A5060755916 @default.
• W2113759125 hasAuthorship W2113759125A5066737605 @default.
• W2113759125 hasAuthorship W2113759125A5089871276 @default.
• W2113759125 hasBestOaLocation W21137591251 @default.
• W2113759125 hasConcept C104317684 @default.
• W2113759125 hasConcept C121332964 @default.
• W2113759125 hasConcept C12554922 @default.
• W2113759125 hasConcept C127162648 @default.
• W2113759125 hasConcept C143065580 @default.
• W2113759125 hasConcept C159467904 @default.
• W2113759125 hasConcept C166342909 @default.
• W2113759125 hasConcept C170493617 @default.
• W2113759125 hasConcept C181199279 @default.
• W2113759125 hasConcept C185592680 @default.
• W2113759125 hasConcept C194544171 @default.
• W2113759125 hasConcept C31258907 @default.
• W2113759125 hasConcept C41008148 @default.
• W2113759125 hasConcept C45516822 @default.
• W2113759125 hasConcept C50254741 @default.
• W2113759125 hasConcept C55493867 @default.
• W2113759125 hasConcept C83743174 @default.
• W2113759125 hasConcept C86803240 @default.
• W2113759125 hasConceptScore W2113759125C104317684 @default.
• W2113759125 hasConceptScore W2113759125C121332964 @default.
• W2113759125 hasConceptScore W2113759125C12554922 @default.
• W2113759125 hasConceptScore W2113759125C127162648 @default.
• W2113759125 hasConceptScore W2113759125C143065580 @default.
• W2113759125 hasConceptScore W2113759125C159467904 @default.
• W2113759125 hasConceptScore W2113759125C166342909 @default.
• W2113759125 hasConceptScore W2113759125C170493617 @default.
• W2113759125 hasConceptScore W2113759125C181199279 @default.
• W2113759125 hasConceptScore W2113759125C185592680 @default.
• W2113759125 hasConceptScore W2113759125C194544171 @default.
• W2113759125 hasConceptScore W2113759125C31258907 @default.
• W2113759125 hasConceptScore W2113759125C41008148 @default.
• W2113759125 hasConceptScore W2113759125C45516822 @default.
• W2113759125 hasConceptScore W2113759125C50254741 @default.
• W2113759125 hasConceptScore W2113759125C55493867 @default.
• W2113759125 hasConceptScore W2113759125C83743174 @default.

• next