FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113759533> ?p ?o ?g. }

• W2113759533 endingPage "270" @default.
• W2113759533 startingPage "265" @default.
• W2113759533 abstract "<i>Background:</i> N-terminally truncated and modified pyroglutamate-3 amyloid-β protein (pE3-Aβ) is present in most, if not all, cerebral plaque and vascular amyloid deposits in human Alzheimer’s disease (AD). pE3-Aβ deposition is also found in AD-like transgenic (tg) mouse brain, albeit in lesser quantities than general Aβ. pE3-Aβ resists degradation, is neurotoxic, and may act as a seed for Aβ aggregation. <i>Objective:</i> We sought to determine if pE3-Aβ removal by passive immunization with a highly specific monoclonal antibody (mAb) impacts pathogenesis in a mouse model of Alzheimer’s amyloidosis. <i>Methods:</i> APPswe/PS1ΔE9 tg mice were given weekly intraperitoneal injections of a new anti-pE3-Aβ mAb (mAb07/1) or PBS from 5.8 to 13.8 months of age (prevention) or from 23 to 24.7 months of age (therapeutic). Multiple forms of cerebral Aβ were quantified pathologically and biochemically. Gliosis and microhemorrhage were examined. <i>Results:</i> Chronic passive immunization with an anti-pE3-Aβ mAb significantly reduced total plaque deposition and appeared to lower gliosis in the hippocampus and cerebellum in both the prevention and therapeutic studies. Insoluble Aβ levels in hemibrain homogenates were not significantly different between immunized and control mice. Microhemorrhage was not observed with anti-pE3-Aβ immunotherapy. <i>Conclusions:</i> Selective removal of pE3-Aβ lowered general Aβ plaque deposition suggesting a pro-aggregation or seeding role for pE3-Aβ." @default.
• W2113759533 created "2016-06-24" @default.
• W2113759533 creator A5001127178 @default.
• W2113759533 creator A5005533718 @default.
• W2113759533 creator A5048371545 @default.
• W2113759533 creator A5048826252 @default.
• W2113759533 creator A5072719225 @default.
• W2113759533 creator A5073976993 @default.
• W2113759533 date "2012-01-01" @default.
• W2113759533 modified "2023-09-23" @default.
• W2113759533 title "Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study" @default.
• W2113759533 cites W1979818695 @default.
• W2113759533 cites W1985323612 @default.
• W2113759533 cites W1988973583 @default.
• W2113759533 cites W1990632702 @default.
• W2113759533 cites W1999017783 @default.
• W2113759533 cites W2005719973 @default.
• W2113759533 cites W2010357514 @default.
• W2113759533 cites W2012288880 @default.
• W2113759533 cites W2024656644 @default.
• W2113759533 cites W2024866120 @default.
• W2113759533 cites W2071310220 @default.
• W2113759533 cites W2074816156 @default.
• W2113759533 cites W2076742349 @default.
• W2113759533 cites W2080705044 @default.
• W2113759533 cites W2086523105 @default.
• W2113759533 cites W2097338951 @default.
• W2113759533 cites W2127458156 @default.
• W2113759533 cites W2130270031 @default.
• W2113759533 cites W2142943752 @default.
• W2113759533 cites W2169152986 @default.
• W2113759533 doi "https://doi.org/10.1159/000335913" @default.
• W2113759533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3702016" @default.
• W2113759533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22343072" @default.
• W2113759533 hasPublicationYear "2012" @default.
• W2113759533 type Work @default.
• W2113759533 sameAs 2113759533 @default.
• W2113759533 citedByCount "62" @default.
• W2113759533 countsByYear W21137595332012 @default.
• W2113759533 countsByYear W21137595332013 @default.
• W2113759533 countsByYear W21137595332014 @default.
• W2113759533 countsByYear W21137595332015 @default.
• W2113759533 countsByYear W21137595332016 @default.
• W2113759533 countsByYear W21137595332017 @default.
• W2113759533 countsByYear W21137595332018 @default.
• W2113759533 countsByYear W21137595332019 @default.
• W2113759533 countsByYear W21137595332020 @default.
• W2113759533 countsByYear W21137595332021 @default.
• W2113759533 countsByYear W21137595332022 @default.
• W2113759533 countsByYear W21137595332023 @default.
• W2113759533 crossrefType "journal-article" @default.
• W2113759533 hasAuthorship W2113759533A5001127178 @default.
• W2113759533 hasAuthorship W2113759533A5005533718 @default.
• W2113759533 hasAuthorship W2113759533A5048371545 @default.
• W2113759533 hasAuthorship W2113759533A5048826252 @default.
• W2113759533 hasAuthorship W2113759533A5072719225 @default.
• W2113759533 hasAuthorship W2113759533A5073976993 @default.
• W2113759533 hasBestOaLocation W21137595331 @default.
• W2113759533 hasConcept C102230213 @default.
• W2113759533 hasConcept C104317684 @default.
• W2113759533 hasConcept C126322002 @default.
• W2113759533 hasConcept C141035611 @default.
• W2113759533 hasConcept C142724271 @default.
• W2113759533 hasConcept C159654299 @default.
• W2113759533 hasConcept C185592680 @default.
• W2113759533 hasConcept C203014093 @default.
• W2113759533 hasConcept C2777633098 @default.
• W2113759533 hasConcept C2777682930 @default.
• W2113759533 hasConcept C2780942790 @default.
• W2113759533 hasConcept C2781161787 @default.
• W2113759533 hasConcept C55493867 @default.
• W2113759533 hasConcept C71924100 @default.
• W2113759533 hasConceptScore W2113759533C102230213 @default.
• W2113759533 hasConceptScore W2113759533C104317684 @default.
• W2113759533 hasConceptScore W2113759533C126322002 @default.
• W2113759533 hasConceptScore W2113759533C141035611 @default.
• W2113759533 hasConceptScore W2113759533C142724271 @default.
• W2113759533 hasConceptScore W2113759533C159654299 @default.
• W2113759533 hasConceptScore W2113759533C185592680 @default.
• W2113759533 hasConceptScore W2113759533C203014093 @default.
• W2113759533 hasConceptScore W2113759533C2777633098 @default.
• W2113759533 hasConceptScore W2113759533C2777682930 @default.
• W2113759533 hasConceptScore W2113759533C2780942790 @default.
• W2113759533 hasConceptScore W2113759533C2781161787 @default.
• W2113759533 hasConceptScore W2113759533C55493867 @default.
• W2113759533 hasConceptScore W2113759533C71924100 @default.
• W2113759533 hasIssue "1-4" @default.
• W2113759533 hasLocation W21137595331 @default.
• W2113759533 hasLocation W21137595332 @default.
• W2113759533 hasLocation W21137595333 @default.
• W2113759533 hasLocation W21137595334 @default.
• W2113759533 hasLocation W21137595335 @default.
• W2113759533 hasOpenAccess W2113759533 @default.
• W2113759533 hasPrimaryLocation W21137595331 @default.
• W2113759533 hasRelatedWork W13298499 @default.
• W2113759533 hasRelatedWork W18352290 @default.
• W2113759533 hasRelatedWork W1977614131 @default.
• W2113759533 hasRelatedWork W1983274526 @default.

• next