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• W2113759967 abstract "In Euplotes crassus, most of the micronuclear genome is eliminated during formation of a transcriptionally active macronucleus. To understand how this is mediated throughout the genome, we have examined the chromatin structure of the macronucleus-destined sequences and Tec transposons, which are dispersed in 15,000 copies in the micronuclear genome and completely eliminated during formation of the macronuclear genome. Whereas the macronucleus-destined sequences show a typical pattern of nucleosomal repeats in micrococcal nuclease digests, the Tec element chromatin structure digests to a nucleosome-like repeat pattern that is not typical: the minimum digestion products are approximately 300-600 base pairs, or subnucleosomal, in size. In addition, the excised, circular forms of the Tec elements are exceedingly resistant to nucleases. Nevertheless, an underlying nucleosomal structure of the Tec elements can be demonstrated from the size differences between repeats in partial micrococcal nuclease digests and by trypsin treatment of nuclei, which results in mononucleosome-sized products. Characterization of the most micrococcal nuclease-resistant DNA indicates that micronuclear telomeres are organized into a chromatin structure with digestion properties identical to those of the Tec elements in the developing macronucleus. Thus, these major repetitive sequence components of the micronuclear genome differ in their chromatin structure from the macronuclear-destined sequences during DNA elimination. The potential role of developmental stage-specific histone variants in this chromatin differentiation is discussed." @default.
• W2113759967 created "2016-06-24" @default.
• W2113759967 creator A5057107154 @default.
• W2113759967 date "1999-12-01" @default.
• W2113759967 modified "2023-09-25" @default.
• W2113759967 title "Differentiation of Chromatin during DNA Elimination inEuplotes crassus" @default.
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• W2113759967 doi "https://doi.org/10.1091/mbc.10.12.4217" @default.
• W2113759967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/25754" @default.
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