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• W2113763350 endingPage "2363" @default.
• W2113763350 startingPage "2358" @default.
• W2113763350 abstract "Abstract Herein, we report a robust total synthesis of dictyostatin. This polyketide natural product has attracted much attention because of its impressive antiproliferative activity against several human cancer‐cell lines. We accomplished its synthesis in a highly convergent manner from three fragments of equal complexity, which were prepared on multigram scale. The southern and northwestern subunits were constructed through application of our o ‐DPPB‐directed hydroformylation and allylic substitution methodology, respectively. These methods generated the C6 and C14 stereocenters of dictyostatin with good diastereoselectivities and simultaneously allowed further elaboration of the fragments by Wittig olefination and Sharpless asymmetric epoxidation, respectively. The compelling performance of the hydroformylation and allylic substitution with regard to practicability, selectivity, and scale underline their value for the construction of propionate motifs." @default.
• W2113763350 created "2016-06-24" @default.
• W2113763350 creator A5067624195 @default.
• W2113763350 creator A5073705287 @default.
• W2113763350 date "2014-12-18" @default.
• W2113763350 modified "2023-10-18" @default.
• W2113763350 title "Probing<i>o</i>-Diphenylphosphanyl Benzoate (<i>o</i>-DPPB)-Directed CC Bond Formation: Total Synthesis of Dictyostatin" @default.
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• W2113763350 doi "https://doi.org/10.1002/chem.201406252" @default.
• W2113763350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25524890" @default.
• W2113763350 hasPublicationYear "2014" @default.
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