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• W2113777868 abstract "ABSTRACT Interferon production and apoptosis in virus-infected cells are necessary to prevent progeny virus production and to eliminate infected cells. Paramyxovirus infection induces apoptosis through interferon regulatory factor 3 (IRF-3), but the exact mechanism of how IRF-3 functions is unknown. We show that IRF-3 is involved in the transcriptional induction of TRAIL, a key player in the apoptosis pathway. IRF-3 upregulates TRAIL transcription following viral infection and binds an interferon-stimulated response element in the TRAIL promoter. The mRNA for TRAIL and its receptor, DR5, are induced following viral infection. These studies identify TRAIL as a novel IRF-3 transcriptional target." @default.
• W2113777868 created "2016-06-24" @default.
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• W2113777868 date "2005-07-01" @default.
• W2113777868 modified "2023-09-25" @default.
• W2113777868 title "Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target" @default.
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• W2113777868 doi "https://doi.org/10.1128/jvi.79.14.9320-9324.2005" @default.
• W2113777868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1168760" @default.
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