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• W2113780941 endingPage "3573" @default.
• W2113780941 startingPage "3565" @default.
• W2113780941 abstract "ABSTRACT We have identified and characterized a Drosophila gene, which we have named sugarless, that encodes a homologue of vertebrate UDP-glucose dehydrogenase. This enzyme is essential for the biosynthesis of various proteoglycans, and we find that in the absence of both maternal and zygotic activities of this gene, mutant embryos develop with segment polarity phenotypes reminiscent to loss of either Wingless or Hedgehog signaling. To analyze the function of Sugarless in cell-cell interaction processes, we have focused our analysis on its requirement for Wingless signaling in different tissues. We report that sugarless mutations impair signaling by Wingless, suggesting that proteoglycans contribute to the reception of Wingless. We demonstrate that overexpression of Wingless can bypass the requirement for sugarless, suggesting that proteoglycans modulate signaling by Wingless, possibly by limiting its diffusion and thereby facilitating the binding of Wingless to its receptor. We discuss the possibility that tissue-specific regulation of proteoglycans may be involved in regulating both Wingless short- or long-range effects." @default.
• W2113780941 created "2016-06-24" @default.
• W2113780941 creator A5043356901 @default.
• W2113780941 creator A5064240182 @default.
• W2113780941 creator A5071083794 @default.
• W2113780941 date "1997-09-15" @default.
• W2113780941 modified "2023-10-16" @default.
• W2113780941 title "The <i>Drosophila sugarless</i> gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis" @default.
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• W2113780941 doi "https://doi.org/10.1242/dev.124.18.3565" @default.
• W2113780941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9342049" @default.
• W2113780941 hasPublicationYear "1997" @default.
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