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- W2113789021 abstract "Abstract Background and Aim We compared the treatment response, survival, and safety to hepatic arterial infusion chemotherapy ( HAIC ) in patients with advanced hepatocellular carcinoma ( HCC ) according to C hild– P ugh ( CP ) score. Methods The study subjects were 249 patients with advanced HCC and CP class A and B who had been treated with HAIC . Patients were grouped according to CP score (5/6, 7 and 8/9) and their tumor response, tolerance, and survival were assessed. Results The median survival time ( MST ) was 8.2, 9.7, 6.3, and 3.9 months for the whole group, patients with CP 5/6, 7 and 8/9, respectively ( P < 0.0001). Complete response ( CR ) and partial response ( PR ) were seen in 11 and 57 patients, respectively, with an overall response rate of 27.3%. The response rate was higher in patients with CP score 5/6 and 7, than CP 8/9 (30.5%, 28.2%, 13.8%). The dropout rate was significantly higher in patients with CP score 8/9 than the other two (8.0%, 12.8%, 33.3%, respectively). The survival rate was significantly better in patients who achieved CR / PR than the others with CP score 5/6, 7. CP score 8/9 was an independent negative factor for response and survival. Conclusion Advanced HCC patients with CP score of 5/6 and 7 showed a better response to HAIC and better prognosis than those with CP score 8/9." @default.
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- W2113789021 date "2012-11-20" @default.
- W2113789021 modified "2023-10-17" @default.
- W2113789021 title "Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma according to Child-Pugh classification" @default.
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- W2113789021 doi "https://doi.org/10.1111/j.1440-1746.2012.07276.x" @default.
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