FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113790562> ?p ?o ?g. }

• W2113790562 endingPage "512" @default.
• W2113790562 startingPage "507" @default.
• W2113790562 abstract "Late-onset Alzheimer's disease (LOAD) is a multifactorial disease with the potential involvement of multiple genes. Four recent genome-wide association studies (GWAS) have found variants showing significant association with LOAD on chromosomes 6, 10, 11, 12, 14, 18, 19, and on the X chromosome. We examined a total of 12 significant SNPs from these studies to determine if the results could be replicated in an independent large case-control sample. We genotyped these 12 SNPs as well the E2/E3/E4 APOE polymorphisms in up to 993 Caucasian Americans with LOAD and up to 976 age-matched healthy Caucasian Americans. We found no statistically significant associations between the 12 SNPs and the risk of AD. Stratification by APOE*4 carrier status also failed to reveal statistically significant associations. Additional analyses were performed to examine potential associations between the 12 SNPs and age-at-onset (AAO) and disease duration among AD cases. Significant associations were observed between AAO and ZNF224/rs3746319 (P = 0.002) and KCNMA1/rs16934131 (P = 0.0066). KCNMA1/rs16934131 also demonstrated statistically significant association with disease duration (P = 0.0002). Although we have been unable to replicate the reported GWAS association with AD risk in our sample, we have identified two new associations with AAO and disease duration that need to be confirmed in additional studies." @default.
• W2113790562 created "2016-06-24" @default.
• W2113790562 creator A5008781173 @default.
• W2113790562 creator A5010114260 @default.
• W2113790562 creator A5018325742 @default.
• W2113790562 creator A5036815556 @default.
• W2113790562 creator A5066625846 @default.
• W2113790562 creator A5068056679 @default.
• W2113790562 creator A5082479521 @default.
• W2113790562 creator A5087465058 @default.
• W2113790562 date "2011-04-07" @default.
• W2113790562 modified "2023-09-23" @default.
• W2113790562 title "Replication study of genome-wide associated SNPs with late-onset Alzheimer's disease" @default.
• W2113790562 cites W2008352401 @default.
• W2113790562 cites W2033552121 @default.
• W2113790562 cites W2053885494 @default.
• W2113790562 cites W2065528657 @default.
• W2113790562 cites W2071172105 @default.
• W2113790562 cites W2097838704 @default.
• W2113790562 cites W2121820194 @default.
• W2113790562 cites W2129494556 @default.
• W2113790562 cites W2147354849 @default.
• W2113790562 cites W2152119060 @default.
• W2113790562 cites W2161633633 @default.
• W2113790562 cites W2166336042 @default.
• W2113790562 cites W2171616229 @default.
• W2113790562 cites W2171998949 @default.
• W2113790562 cites W3214092816 @default.
• W2113790562 doi "https://doi.org/10.1002/ajmg.b.31194" @default.
• W2113790562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3082594" @default.
• W2113790562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21480501" @default.
• W2113790562 hasPublicationYear "2011" @default.
• W2113790562 type Work @default.
• W2113790562 sameAs 2113790562 @default.
• W2113790562 citedByCount "19" @default.
• W2113790562 countsByYear W21137905622012 @default.
• W2113790562 countsByYear W21137905622013 @default.
• W2113790562 countsByYear W21137905622014 @default.
• W2113790562 countsByYear W21137905622015 @default.
• W2113790562 countsByYear W21137905622016 @default.
• W2113790562 countsByYear W21137905622018 @default.
• W2113790562 countsByYear W21137905622019 @default.
• W2113790562 countsByYear W21137905622020 @default.
• W2113790562 countsByYear W21137905622021 @default.
• W2113790562 countsByYear W21137905622022 @default.
• W2113790562 crossrefType "journal-article" @default.
• W2113790562 hasAuthorship W2113790562A5008781173 @default.
• W2113790562 hasAuthorship W2113790562A5010114260 @default.
• W2113790562 hasAuthorship W2113790562A5018325742 @default.
• W2113790562 hasAuthorship W2113790562A5036815556 @default.
• W2113790562 hasAuthorship W2113790562A5066625846 @default.
• W2113790562 hasAuthorship W2113790562A5068056679 @default.
• W2113790562 hasAuthorship W2113790562A5082479521 @default.
• W2113790562 hasAuthorship W2113790562A5087465058 @default.
• W2113790562 hasBestOaLocation W21137905622 @default.
• W2113790562 hasConcept C104317684 @default.
• W2113790562 hasConcept C106208931 @default.
• W2113790562 hasConcept C126322002 @default.
• W2113790562 hasConcept C135763542 @default.
• W2113790562 hasConcept C146304588 @default.
• W2113790562 hasConcept C153209595 @default.
• W2113790562 hasConcept C186413461 @default.
• W2113790562 hasConcept C2777767895 @default.
• W2113790562 hasConcept C2779134260 @default.
• W2113790562 hasConcept C54355233 @default.
• W2113790562 hasConcept C57089818 @default.
• W2113790562 hasConcept C71924100 @default.
• W2113790562 hasConcept C86803240 @default.
• W2113790562 hasConceptScore W2113790562C104317684 @default.
• W2113790562 hasConceptScore W2113790562C106208931 @default.
• W2113790562 hasConceptScore W2113790562C126322002 @default.
• W2113790562 hasConceptScore W2113790562C135763542 @default.
• W2113790562 hasConceptScore W2113790562C146304588 @default.
• W2113790562 hasConceptScore W2113790562C153209595 @default.
• W2113790562 hasConceptScore W2113790562C186413461 @default.
• W2113790562 hasConceptScore W2113790562C2777767895 @default.
• W2113790562 hasConceptScore W2113790562C2779134260 @default.
• W2113790562 hasConceptScore W2113790562C54355233 @default.
• W2113790562 hasConceptScore W2113790562C57089818 @default.
• W2113790562 hasConceptScore W2113790562C71924100 @default.
• W2113790562 hasConceptScore W2113790562C86803240 @default.
• W2113790562 hasIssue "4" @default.
• W2113790562 hasLocation W21137905621 @default.
• W2113790562 hasLocation W21137905622 @default.
• W2113790562 hasLocation W21137905623 @default.
• W2113790562 hasLocation W21137905624 @default.
• W2113790562 hasOpenAccess W2113790562 @default.
• W2113790562 hasPrimaryLocation W21137905621 @default.
• W2113790562 hasRelatedWork W2059835894 @default.
• W2113790562 hasRelatedWork W2113790562 @default.
• W2113790562 hasRelatedWork W2125747516 @default.
• W2113790562 hasRelatedWork W2471274516 @default.
• W2113790562 hasRelatedWork W2884987722 @default.
• W2113790562 hasRelatedWork W2888335178 @default.
• W2113790562 hasRelatedWork W3029018258 @default.
• W2113790562 hasRelatedWork W4200042319 @default.
• W2113790562 hasRelatedWork W4236109978 @default.
• W2113790562 hasRelatedWork W2738474533 @default.

• next