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- W2113802972 endingPage "226" @default.
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- W2113802972 abstract "The demonstration by Yaksh and Rudy (1) that intrathecal morphine in rats produced long-lasting, dose-dependent, and naloxonereversible analgesia led to the first use of spinal opioids in humans by Wang et al. (2) in 1979. Within months after the publication of this study of intrathecal morphine in cancer patients, Behar et al. (3) reported the epidural use of morphine in 10 patients and Cousins et al. (4) reported epidural use of meperidine. In the latter study, it was found that the time course of analgesia correlated with that of CSF rather than plasma meperidine concentrations, thus indicating a spinal site of action." @default.
- W2113802972 created "2016-06-24" @default.
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- W2113802972 creator A5054312557 @default.
- W2113802972 date "1994-01-01" @default.
- W2113802972 modified "2023-10-16" @default.
- W2113802972 title "The Spinal Route of Analgesia: Opioids and Future Options" @default.
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