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• W2113803040 endingPage "859" @default.
• W2113803040 startingPage "847" @default.
• W2113803040 abstract "Mutations in the hook gene alter intracellular trafficking of internalized ligands in Drosophila. To dissect this defect in more detail, we developed a new approach to visualize the pathway taken by the Bride of Sevenless (Boss) ligand after its internalization into R7 cells. A chimeric protein consisting of HRP fused to Boss (HRP-Boss) was expressed in R8 cells. This chimera was fully functional: it rescued the boss mutant phenotype, and its trafficking was indistinguishable from that of the wild-type Boss protein. The HRP activity of the chimera was used to follow HRP-Boss trafficking on the ultrastructural level through early and late endosomes in R7 cells. In both wild-type andhook mutant eye disks, HRP-Boss was internalized into R7 cells. In wild-type tissue, Boss accumulated in mature multivesicular bodies (MVBs) within R7 cells; such accumulation was not observed in hook eye disks, however. Quantitative electron microscopy revealed a loss of mature MVBs inhook mutant tissue compared with wild type, whereas more than twice as many multilammelar late endosomes were detected. Our genetic analysis indicates that Hook is required late in endocytic trafficking to negatively regulate delivery from mature MVBs to multilammelar late endosomes and lysosomes." @default.
• W2113803040 created "2016-06-24" @default.
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• W2113803040 date "1999-04-01" @default.
• W2113803040 modified "2023-09-27" @default.
• W2113803040 title "Genetic Dissection of Endocytic Trafficking in<i>Drosophila</i>Using a Horseradish Peroxidase-Bride of Sevenless Chimera:<i>hook</i>Is Required for Normal Maturation of Multivesicular Endosomes" @default.
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• W2113803040 doi "https://doi.org/10.1091/mbc.10.4.847" @default.
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