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• W2113805241 abstract "Literature dealing with antituberculosis chemotherapy of tuberculous meningitis (TBM) in adults and children is reviewed and recommendations made for the chemotherapy of TBM. Publications relating to the chemotherapy of TBM were reviewed which contribute to understanding the efficacy of different drugs and regimens in TBM treatment. The established classification of disease severity into stages I (no neurological signs and fully conscious), II (patients conscious but with neurological signs) and III (comatose or stuporous or with severe pareses) was used to compare regimens of isoniazid (INH), para-amino salicylic acid and streptomycin (INH regimens) used up to approximately 1970 with those using INH and rifampicin (RMP), supported by pyrazinamide and ethambutol or streptomycin (RMP regimens). Mortality in studies at all disease stages in adults or adults and children, with the children not distinguished, following INH regimens (12.4%, 25.2% and 55% at stages I, II and III respectively) did not differ significantly from that following introduction of RMP regimens (9.7%, 22.2% and 56% at stages I, II and III respectively), In studies of children only, mortality fell significantly following the introduction of RMP to 0%, 5.9% and 28.2% in children at stage I, II and III having been 10.2%, 22.3% and 49.4% respectively with INH regimens (P = 0.006). Following RMP regimens of 6 months duration, only 2 (1%) relapses occurred amongst 197 patients, after RMP regimens of 9–24 months only 1 (0.16%) relapse was recorded amongst 632 patients. Where INH resistance rates are <4% a directly observed INH, RMP, pyrazinamide and ethambutol for 2-months followed by INH and RMP for 4 months is recommended. If directly observed therapy cannot be practiced treatment duration should be extended to at least 9 months; if the risk of INH resistance or multidrug resistance is higher, the use of ethionamide and a fluoroquinolone and possibly cycloserine is recommended and pyrazinamide should be continued for full treatment duration. The penetration of RMP, ethambutol and streptomycin into cerebrospinal fluid is poor; higher dosages of RMP should be considered." @default.
• W2113805241 created "2016-06-24" @default.
• W2113805241 creator A5080320442 @default.
• W2113805241 date "2010-11-01" @default.
• W2113805241 modified "2023-09-27" @default.
• W2113805241 title "The chemotherapy of tuberculous meningitis in children and adults" @default.
• W2113805241 cites W1506168917 @default.
• W2113805241 cites W1518121730 @default.
• W2113805241 cites W1528415257 @default.
• W2113805241 cites W1531285100 @default.
• W2113805241 cites W1572606009 @default.
• W2113805241 cites W1592450098 @default.
• W2113805241 cites W1757387857 @default.
• W2113805241 cites W187372423 @default.
• W2113805241 cites W1967905331 @default.
• W2113805241 cites W1968039152 @default.
• W2113805241 cites W1968414436 @default.
• W2113805241 cites W1970000433 @default.
• W2113805241 cites W1971111317 @default.
• W2113805241 cites W1971287488 @default.
• W2113805241 cites W1978604305 @default.
• W2113805241 cites W1980993641 @default.
• W2113805241 cites W1981188231 @default.
• W2113805241 cites W1983030828 @default.
• W2113805241 cites W1989674501 @default.
• W2113805241 cites W1992134810 @default.
• W2113805241 cites W1995215287 @default.
• W2113805241 cites W2001856619 @default.
• W2113805241 cites W2003425709 @default.
• W2113805241 cites W2004815652 @default.
• W2113805241 cites W2004870123 @default.
• W2113805241 cites W2010782708 @default.
• W2113805241 cites W2011397110 @default.
• W2113805241 cites W2017923181 @default.
• W2113805241 cites W2027333630 @default.
• W2113805241 cites W2032883826 @default.
• W2113805241 cites W2034378640 @default.
• W2113805241 cites W2035407420 @default.
• W2113805241 cites W2036801841 @default.
• W2113805241 cites W2038826236 @default.
• W2113805241 cites W2043157876 @default.
• W2113805241 cites W2044865198 @default.
• W2113805241 cites W2045392819 @default.
• W2113805241 cites W2049022058 @default.
• W2113805241 cites W2049689583 @default.
• W2113805241 cites W2053309807 @default.
• W2113805241 cites W2054393627 @default.
• W2113805241 cites W2055036143 @default.
• W2113805241 cites W2055907855 @default.
• W2113805241 cites W2058307888 @default.
• W2113805241 cites W2060243542 @default.
• W2113805241 cites W2070406924 @default.
• W2113805241 cites W2072475014 @default.
• W2113805241 cites W2073949468 @default.
• W2113805241 cites W2075913852 @default.
• W2113805241 cites W2084796500 @default.
• W2113805241 cites W2086229059 @default.
• W2113805241 cites W2091216369 @default.
• W2113805241 cites W2092587768 @default.
• W2113805241 cites W2094327446 @default.
• W2113805241 cites W2095093151 @default.
• W2113805241 cites W2096343172 @default.
• W2113805241 cites W2097465589 @default.
• W2113805241 cites W2097792882 @default.
• W2113805241 cites W2106847709 @default.
• W2113805241 cites W2108409631 @default.
• W2113805241 cites W2109155079 @default.
• W2113805241 cites W2114698696 @default.
• W2113805241 cites W2120390077 @default.
• W2113805241 cites W2120484996 @default.
• W2113805241 cites W2128022231 @default.
• W2113805241 cites W2128705134 @default.
• W2113805241 cites W2144322748 @default.
• W2113805241 cites W2146861016 @default.
• W2113805241 cites W2157027583 @default.
• W2113805241 cites W2165809507 @default.
• W2113805241 cites W2166680224 @default.
• W2113805241 cites W2166886575 @default.
• W2113805241 cites W2170523129 @default.
• W2113805241 cites W2171124812 @default.
• W2113805241 cites W2241817324 @default.
• W2113805241 cites W2319802744 @default.
• W2113805241 cites W2337243417 @default.
• W2113805241 cites W2338888534 @default.
• W2113805241 cites W4234155942 @default.
• W2113805241 cites W4241434358 @default.
• W2113805241 cites W4243828373 @default.
• W2113805241 cites W4246059571 @default.
• W2113805241 cites W4251922180 @default.
• W2113805241 cites W4253099240 @default.
• W2113805241 cites W4385997046 @default.
• W2113805241 cites W44356564 @default.
• W2113805241 cites W2034945094 @default.
• W2113805241 doi "https://doi.org/10.1016/j.tube.2010.07.003" @default.
• W2113805241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20810322" @default.
• W2113805241 hasPublicationYear "2010" @default.
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