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- W2113806491 abstract "One potentially promising strategy to control chronic infections such as human immunodeficiency virus, hepatitis B virus, and hepatitis C virus is therapeutic vaccination, which aims to reduce persisting virus by stimulating a patient's own antiviral immune responses. However, this approach has fallen short of expectations, because antiviral T cells generated during chronic infections often become functionally exhausted and thus do not respond properly to therapeutic vaccination. Therefore, it is necessary to develop a therapeutic vaccine strategy to more effectively boost endogenous T-cell responses to control persistent viral infections. Studies to elucidate the cause of impaired T-cell function have pointed to sustained inhibitory receptor signaling through T-cell expression of programmed death 1 (PD-1). Recently, another inhibitory molecule, cytotoxic T lymphocyte antigen 4 (CTLA-4), and also an immunosuppressive cytokine, interleukin 10 (IL-10), have been reported to be potential factors of establishing immune suppression and viral persistence. Blocking these negative signaling pathways could restore the host immune system, enabling it to respond to further stimulation. Indeed, combining therapeutic vaccination along with the blockade of inhibitory signals could synergistically enhance functional CD8(+) T-cell responses and improve viral control in chronically infected mice, providing a promising strategy for the treatment of chronic viral infections. Furthermore, not only the ablation of negative signals but also the addition of stimulatory signals, such as interleukin 2 (IL-2), might prove to be a potentially promising strategy to augment the efficacy of therapeutic vaccination against chronic viral infections." @default.
- W2113806491 created "2016-06-24" @default.
- W2113806491 creator A5003546968 @default.
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- W2113806491 creator A5043198774 @default.
- W2113806491 date "2008-06-01" @default.
- W2113806491 modified "2023-10-10" @default.
- W2113806491 title "Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections" @default.
- W2113806491 cites W116884621 @default.
- W2113806491 cites W1500258913 @default.
- W2113806491 cites W1511803520 @default.
- W2113806491 cites W1515615230 @default.
- W2113806491 cites W1536480181 @default.
- W2113806491 cites W1544285519 @default.
- W2113806491 cites W1546847318 @default.
- W2113806491 cites W1573470869 @default.
- W2113806491 cites W1581904411 @default.
- W2113806491 cites W1585454314 @default.
- W2113806491 cites W1601504908 @default.
- W2113806491 cites W1602273859 @default.
- W2113806491 cites W1605483703 @default.
- W2113806491 cites W1617728256 @default.
- W2113806491 cites W1633418194 @default.
- W2113806491 cites W1775395314 @default.
- W2113806491 cites W1823207 @default.
- W2113806491 cites W1919948406 @default.
- W2113806491 cites W1945834141 @default.
- W2113806491 cites W1959184859 @default.
- W2113806491 cites W1960303690 @default.
- W2113806491 cites W1965085022 @default.
- W2113806491 cites W1965776393 @default.
- W2113806491 cites W1968276891 @default.
- W2113806491 cites W1968738098 @default.
- W2113806491 cites W1970128046 @default.
- W2113806491 cites W1976725250 @default.
- W2113806491 cites W1978436252 @default.
- W2113806491 cites W1979982823 @default.
- W2113806491 cites W1981030283 @default.
- W2113806491 cites W1981060816 @default.
- W2113806491 cites W1981136135 @default.
- W2113806491 cites W1983996031 @default.
- W2113806491 cites W1984781939 @default.
- W2113806491 cites W1985547915 @default.
- W2113806491 cites W1987155012 @default.
- W2113806491 cites W1992048975 @default.
- W2113806491 cites W1993617345 @default.
- W2113806491 cites W1994433593 @default.
- W2113806491 cites W1994975885 @default.
- W2113806491 cites W1996464851 @default.
- W2113806491 cites W1996642272 @default.
- W2113806491 cites W1997276741 @default.
- W2113806491 cites W2001137507 @default.
- W2113806491 cites W2001815433 @default.
- W2113806491 cites W2004815678 @default.
- W2113806491 cites W2006190883 @default.
- W2113806491 cites W2006607638 @default.
- W2113806491 cites W2007024686 @default.
- W2113806491 cites W2012136501 @default.
- W2113806491 cites W2013068560 @default.
- W2113806491 cites W2014116920 @default.
- W2113806491 cites W2014428225 @default.
- W2113806491 cites W2015095769 @default.
- W2113806491 cites W2015199158 @default.
- W2113806491 cites W2015336471 @default.
- W2113806491 cites W2018217171 @default.
- W2113806491 cites W2018710900 @default.
- W2113806491 cites W2019969899 @default.
- W2113806491 cites W2022057836 @default.
- W2113806491 cites W2025741354 @default.
- W2113806491 cites W2027932439 @default.
- W2113806491 cites W2028376975 @default.
- W2113806491 cites W2030605921 @default.
- W2113806491 cites W2031477951 @default.
- W2113806491 cites W2032063778 @default.
- W2113806491 cites W2032955836 @default.
- W2113806491 cites W2035852466 @default.
- W2113806491 cites W2037328479 @default.
- W2113806491 cites W2039415249 @default.
- W2113806491 cites W2044757144 @default.
- W2113806491 cites W2046775408 @default.
- W2113806491 cites W2048901584 @default.
- W2113806491 cites W2049195346 @default.
- W2113806491 cites W2050466666 @default.
- W2113806491 cites W2055522356 @default.
- W2113806491 cites W2056242148 @default.
- W2113806491 cites W2057499380 @default.
- W2113806491 cites W2058636963 @default.
- W2113806491 cites W2063022052 @default.
- W2113806491 cites W2065557750 @default.
- W2113806491 cites W2066719237 @default.
- W2113806491 cites W2068993874 @default.
- W2113806491 cites W2069968817 @default.
- W2113806491 cites W2072056970 @default.
- W2113806491 cites W2073657821 @default.
- W2113806491 cites W2075819066 @default.
- W2113806491 cites W2077605240 @default.