FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113809180> ?p ?o ?g. }

• W2113809180 endingPage "2745" @default.
• W2113809180 startingPage "2732" @default.
• W2113809180 abstract "Ras activation is crucial for lymphocyte development and effector function. Both T and B lymphocytes contain two types of Ras activators: ubiquitously expressed SOS and specifically expressed Ras guanyl nucleotide-releasing protein (RasGRP). The need for two activators is enigmatic since both are activated following antigen receptor stimulation. In addition, RasGRP1 appears to be dominant over SOS in an unknown manner. The crystal structure of SOS provides a clue: an unusual allosteric Ras-GTP binding pocket. Here, we demonstrate that RasGRP orchestrates Ras signaling in two ways: (i) by activating Ras directly and (ii) by facilitating priming of SOS with RasGTP that binds the allosteric pocket. Priming enhances SOS' in vivo activity and creates a positive RasGTP-SOS feedback loop that functions as a rheostat for Ras activity. Without RasGRP1, initiation of this loop is impaired because SOS' catalyst is its own product (RasGTP)—hence the dominance of RasGRP1. Introduction of an active Ras-like molecule (RasV12C40) in T- and B-cell lines can substitute for RasGRP function and enhance SOS' activity via its allosteric pocket. The unusual RasGRP-SOS interplay results in sensitive and robust Ras activation that cannot be achieved with either activator alone. We hypothesize that this mechanism enables lymphocytes to maximally respond to physiologically low levels of stimulation." @default.
• W2113809180 created "2016-06-24" @default.
• W2113809180 creator A5042371608 @default.
• W2113809180 creator A5050836076 @default.
• W2113809180 creator A5057097524 @default.
• W2113809180 creator A5086092084 @default.
• W2113809180 creator A5089401028 @default.
• W2113809180 date "2007-04-01" @default.
• W2113809180 modified "2023-10-01" @default.
• W2113809180 title "Unusual Interplay of Two Types of Ras Activators, RasGRP and SOS, Establishes Sensitive and Robust Ras Activation in Lymphocytes" @default.
• W2113809180 cites W1544291870 @default.
• W2113809180 cites W1598625800 @default.
• W2113809180 cites W1970694857 @default.
• W2113809180 cites W1973189139 @default.
• W2113809180 cites W1986807291 @default.
• W2113809180 cites W1988409513 @default.
• W2113809180 cites W1993163893 @default.
• W2113809180 cites W1999824494 @default.
• W2113809180 cites W2002440150 @default.
• W2113809180 cites W2004872546 @default.
• W2113809180 cites W2009484032 @default.
• W2113809180 cites W2022840517 @default.
• W2113809180 cites W2029149519 @default.
• W2113809180 cites W2031272027 @default.
• W2113809180 cites W2033068296 @default.
• W2113809180 cites W2051541090 @default.
• W2113809180 cites W2052371969 @default.
• W2113809180 cites W2052750950 @default.
• W2113809180 cites W2052799365 @default.
• W2113809180 cites W2055825597 @default.
• W2113809180 cites W2057193041 @default.
• W2113809180 cites W2064293764 @default.
• W2113809180 cites W2069800089 @default.
• W2113809180 cites W2090171844 @default.
• W2113809180 cites W2093902610 @default.
• W2113809180 cites W2093933397 @default.
• W2113809180 cites W2113786709 @default.
• W2113809180 cites W2123659424 @default.
• W2113809180 cites W2131566341 @default.
• W2113809180 cites W2151782442 @default.
• W2113809180 cites W2155947794 @default.
• W2113809180 cites W2156470803 @default.
• W2113809180 cites W2157234510 @default.
• W2113809180 cites W2157519884 @default.
• W2113809180 cites W2160451821 @default.
• W2113809180 cites W2163850801 @default.
• W2113809180 cites W2165562009 @default.
• W2113809180 cites W2168209933 @default.
• W2113809180 cites W4239755020 @default.
• W2113809180 cites W4246590628 @default.
• W2113809180 cites W4247904703 @default.
• W2113809180 doi "https://doi.org/10.1128/mcb.01882-06" @default.
• W2113809180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1899892" @default.
• W2113809180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17283063" @default.
• W2113809180 hasPublicationYear "2007" @default.
• W2113809180 type Work @default.
• W2113809180 sameAs 2113809180 @default.
• W2113809180 citedByCount "148" @default.
• W2113809180 countsByYear W21138091802012 @default.
• W2113809180 countsByYear W21138091802013 @default.
• W2113809180 countsByYear W21138091802014 @default.
• W2113809180 countsByYear W21138091802015 @default.
• W2113809180 countsByYear W21138091802016 @default.
• W2113809180 countsByYear W21138091802017 @default.
• W2113809180 countsByYear W21138091802018 @default.
• W2113809180 countsByYear W21138091802019 @default.
• W2113809180 countsByYear W21138091802020 @default.
• W2113809180 countsByYear W21138091802021 @default.
• W2113809180 countsByYear W21138091802023 @default.
• W2113809180 crossrefType "journal-article" @default.
• W2113809180 hasAuthorship W2113809180A5042371608 @default.
• W2113809180 hasAuthorship W2113809180A5050836076 @default.
• W2113809180 hasAuthorship W2113809180A5057097524 @default.
• W2113809180 hasAuthorship W2113809180A5086092084 @default.
• W2113809180 hasAuthorship W2113809180A5089401028 @default.
• W2113809180 hasBestOaLocation W21138091802 @default.
• W2113809180 hasConcept C100701293 @default.
• W2113809180 hasConcept C118716 @default.
• W2113809180 hasConcept C126619667 @default.
• W2113809180 hasConcept C166342909 @default.
• W2113809180 hasConcept C170493617 @default.
• W2113809180 hasConcept C181199279 @default.
• W2113809180 hasConcept C207332259 @default.
• W2113809180 hasConcept C51785407 @default.
• W2113809180 hasConcept C55493867 @default.
• W2113809180 hasConcept C59822182 @default.
• W2113809180 hasConcept C81444415 @default.
• W2113809180 hasConcept C86803240 @default.
• W2113809180 hasConcept C88045685 @default.
• W2113809180 hasConcept C95444343 @default.
• W2113809180 hasConceptScore W2113809180C100701293 @default.
• W2113809180 hasConceptScore W2113809180C118716 @default.
• W2113809180 hasConceptScore W2113809180C126619667 @default.
• W2113809180 hasConceptScore W2113809180C166342909 @default.
• W2113809180 hasConceptScore W2113809180C170493617 @default.
• W2113809180 hasConceptScore W2113809180C181199279 @default.
• W2113809180 hasConceptScore W2113809180C207332259 @default.
• W2113809180 hasConceptScore W2113809180C51785407 @default.

• next