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• W2113809188 abstract "Of 534 human primary breast cancers provided for clonogenic assay in vitro, 276 (51.7%) developed distinctive colony formation by the soft-agar method. Estrogen receptors (ERs) were assayed by dextran-coated charcoal methods. A total of 65 (23.7%) of 274 breast cancers responded to added 10 n M 17β-estra-diol (E2) by an increase in the number of colonies per dish of 150% or more of that in the controls treated with dextran-coated charcoal. The ER-positive and ER-negative tumors differed significantly in their response to E2: 55 (29.9%) of 184 ER-positive tumors responded versus 10 (11.1%) of 90 ER-negative tumors. The cancers in which the number of colonies increased to 150% or more of that of the controls were considered to be estrogen dependent; those in which the number of colonies increased to less than 150% of the control values were considered to be estrogen independent. When 1 μ M ta-moxifen (TMX) was added to the medium, 48 (21.3%) of 225 cancers showed a decrease in the number of colonies to 50% or less of that of the controls. Thus, we could separate breast cancers that were TMX sensitive (No. of colonies ≤50% of that of controls) from those that were TMX resistant (No. of colonies >50% of that of controls). The response to TMX of the ER-positive cancers was significantly higher than that of the ER-negative tumors: 39 (25.5%) of 153 ER-positive tumors responded versus nine (12.5%) of 72 ER-negative tumors. In 153 ER-positive and 71 ER-negative tumors, we evaluated the correlation between the response to E2 and the response to TMX. ER-positive and ER-negative tumors differed significantly in their sensitivities to the two drugs. The TMX sensitivity did not completely correlate with the E2 dependence. The discrepancy (i.e., estrogen dependent-TMX resistant and estrogen independent-TMX sensitive) was seen more frequently in the ER-positive tumors. These results suggest that this clonogenic assay can be used to predict the dependence of an individual breast cancer on a specific hormonal agent. Furthermore, they indicate the existence of different mechanism(s) of hormone dependence of breast cancer cells on E2 and TMX." @default.
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• W2113809188 date "1990-07-04" @default.
• W2113809188 modified "2023-09-27" @default.
• W2113809188 title "Differential Effects of Estrogen and Antiestrogen on In Vitro Clonogenic Growth of Human Breast Cancers in Soft Agar" @default.
• W2113809188 doi "https://doi.org/10.1093/jnci/82.13.1146" @default.
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