FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113855963> ?p ?o ?g. }

• W2113855963 endingPage "3050" @default.
• W2113855963 startingPage "3042" @default.
• W2113855963 abstract "Calsequestrin (CASQ) serves as a major Ca(2+) storage/buffer protein in the sarcoplasmic reticulum (SR). When purified from skeletal muscle, CASQ1 is obtained in its glycosylated form. Here, we have confirmed the specific site and degree of glycosylation of native rabbit CASQ1 and have investigated its effect on critical properties of CASQ by comparison with the non-glycosylated recombinant form. Based on our comparative approach utilizing crystal structures, Ca(2+) binding capacities, analytical ultracentrifugation, and light-scattering profiles of the native and recombinant rabbit CASQ1, we propose a novel and dynamic role for glycosylation in CASQ. CASQ undergoes a unique degree of mannose trimming as it is trafficked from the proximal endoplasmic reticulum to the SR. The major glycoform of CASQ (GlcNAc(2)Man(9)) found in the proximal endoplasmic reticulum can severely hinder formation of the back-to-back interface, potentially preventing premature Ca(2+)-dependent polymerization of CASQ and ensuring its continuous mobility to the SR. Only trimmed glycans can stabilize both front-to-front and the back-to-back interfaces of CASQ through extensive hydrogen bonding and electrostatic interactions. Therefore, the mature glycoform of CASQ (GlcNAc(2)Man(1-4)) within the SR can be retained upon establishing a functional high capacity Ca(2+) binding polymer. In addition, based on the high resolution structures, we propose a molecular mechanism for the catecholaminergic polymorphic ventricular tachycardia (CPVT2) mutation, K206N." @default.
• W2113855963 created "2016-06-24" @default.
• W2113855963 creator A5059915325 @default.
• W2113855963 creator A5071667418 @default.
• W2113855963 creator A5083361673 @default.
• W2113855963 creator A5087884831 @default.
• W2113855963 creator A5061409834 @default.
• W2113855963 date "2012-01-01" @default.
• W2113855963 modified "2023-10-18" @default.
• W2113855963 title "Glycosylation of Skeletal Calsequestrin" @default.
• W2113855963 cites W1509611865 @default.
• W2113855963 cites W1510616039 @default.
• W2113855963 cites W1527461658 @default.
• W2113855963 cites W1531765690 @default.
• W2113855963 cites W1539796472 @default.
• W2113855963 cites W1553674554 @default.
• W2113855963 cites W1576981355 @default.
• W2113855963 cites W162876264 @default.
• W2113855963 cites W1858204783 @default.
• W2113855963 cites W1965095855 @default.
• W2113855963 cites W1966339013 @default.
• W2113855963 cites W1971833900 @default.
• W2113855963 cites W1979437797 @default.
• W2113855963 cites W1979729411 @default.
• W2113855963 cites W1985693035 @default.
• W2113855963 cites W1987523382 @default.
• W2113855963 cites W1988335738 @default.
• W2113855963 cites W1989553550 @default.
• W2113855963 cites W2002885745 @default.
• W2113855963 cites W2007709380 @default.
• W2113855963 cites W2016850966 @default.
• W2113855963 cites W2023825631 @default.
• W2113855963 cites W2024392339 @default.
• W2113855963 cites W2025514694 @default.
• W2113855963 cites W2028062152 @default.
• W2113855963 cites W2028421228 @default.
• W2113855963 cites W2032894671 @default.
• W2113855963 cites W2033012987 @default.
• W2113855963 cites W2033319529 @default.
• W2113855963 cites W2040470885 @default.
• W2113855963 cites W2040794750 @default.
• W2113855963 cites W2046176223 @default.
• W2113855963 cites W2050171893 @default.
• W2113855963 cites W2057515498 @default.
• W2113855963 cites W2059538991 @default.
• W2113855963 cites W2061177065 @default.
• W2113855963 cites W2063389269 @default.
• W2113855963 cites W2068653808 @default.
• W2113855963 cites W2069698030 @default.
• W2113855963 cites W2072198852 @default.
• W2113855963 cites W2075970710 @default.
• W2113855963 cites W2080289073 @default.
• W2113855963 cites W2082657939 @default.
• W2113855963 cites W2097688250 @default.
• W2113855963 cites W2100310965 @default.
• W2113855963 cites W2102025585 @default.
• W2113855963 cites W2133243950 @default.
• W2113855963 cites W2143283321 @default.
• W2113855963 cites W2144081223 @default.
• W2113855963 cites W2163547302 @default.
• W2113855963 cites W2165642078 @default.
• W2113855963 cites W2168013049 @default.
• W2113855963 cites W2180229411 @default.
• W2113855963 cites W3091270580 @default.
• W2113855963 cites W4245915136 @default.
• W2113855963 doi "https://doi.org/10.1074/jbc.m111.326363" @default.
• W2113855963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3270961" @default.
• W2113855963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22170046" @default.
• W2113855963 hasPublicationYear "2012" @default.
• W2113855963 type Work @default.
• W2113855963 sameAs 2113855963 @default.
• W2113855963 citedByCount "19" @default.
• W2113855963 countsByYear W21138559632012 @default.
• W2113855963 countsByYear W21138559632013 @default.
• W2113855963 countsByYear W21138559632014 @default.
• W2113855963 countsByYear W21138559632015 @default.
• W2113855963 countsByYear W21138559632016 @default.
• W2113855963 countsByYear W21138559632019 @default.
• W2113855963 countsByYear W21138559632020 @default.
• W2113855963 countsByYear W21138559632021 @default.
• W2113855963 countsByYear W21138559632022 @default.
• W2113855963 countsByYear W21138559632023 @default.
• W2113855963 crossrefType "journal-article" @default.
• W2113855963 hasAuthorship W2113855963A5059915325 @default.
• W2113855963 hasAuthorship W2113855963A5061409834 @default.
• W2113855963 hasAuthorship W2113855963A5071667418 @default.
• W2113855963 hasAuthorship W2113855963A5083361673 @default.
• W2113855963 hasAuthorship W2113855963A5087884831 @default.
• W2113855963 hasBestOaLocation W21138559631 @default.
• W2113855963 hasConcept C113217602 @default.
• W2113855963 hasConcept C12554922 @default.
• W2113855963 hasConcept C158617107 @default.
• W2113855963 hasConcept C185592680 @default.
• W2113855963 hasConcept C2775953344 @default.
• W2113855963 hasConcept C2777313579 @default.
• W2113855963 hasConcept C55493867 @default.
• W2113855963 hasConcept C86803240 @default.
• W2113855963 hasConcept C95444343 @default.

• next