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• W2113856675 abstract "DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials DAO 84:243-250 (2009) - DOI: https://doi.org/10.3354/dao02052 Use of oxytetracycline for the treatment of tremor disease in the Chinese mitten crab Eriocheir sinensis Tingming Liang, Qi Feng, Ting Wu, Wei Gu, Wen Wang* Jiangsu Key Laboratory for Biodiversity & Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, PR China *Corresponding author. Email: njnuwang@263.net ABSTRACT: The causative agent of tremor disease (TD) in the Chinese mitten crab Eriocheir sinensis has been shown to be a member of the genus Spiroplasma. In the present study, a susceptibility test indicated that oxytetracycline (OTC) has both a high degree of efficacy in the inhibition of Spiroplasma and a broad range of safe concentrations. Treatment experiments showed that the best concentration of OTC for use against TD was 40 mg OTC kg–1 crab weight. Acute toxicity experiments demonstrated that the 24 and 48 h median lethal dosages (LD50) of OTC for this species of crab were 366 and 340 mg OTC kg–1 crab body weight, respectively, while the safe concentration was 82.5 mg OTC kg–1 crab weight. We suggest that OTC has potential as a highly effective inhibitor of Spiroplasma pathogens in aquatic animals and has been proven to be a potent, safe and low cost cure for TD. This represents a novel use of OTC in the therapeutic treatment of an aquacultural disease caused by a Spiroplasma pathogen. KEY WORDS: Oxytetracycline · Spiroplasma · Tremor disease · Acute toxicity · Chinese mitten crab · Eriocheir sinensis Full text in pdf format PreviousNextCite this article as: Liang T, Feng Q, Wu T, Gu W, Wang W (2009) Use of oxytetracycline for the treatment of tremor disease in the Chinese mitten crab Eriocheir sinensis. Dis Aquat Org 84:243-250. https://doi.org/10.3354/dao02052 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in DAO Vol. 84, No. 3. Online publication date: April 27, 2009 Print ISSN: 0177-5103; Online ISSN: 1616-1580 Copyright © 2009 Inter-Research." @default.
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• W2113856675 date "2009-04-27" @default.
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• W2113856675 title "Use of oxytetracycline for the treatment of tremor disease in the Chinese mitten crab Eriocheir sinensis" @default.
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