Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113862969> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2113862969 endingPage "1602" @default.
- W2113862969 startingPage "1597" @default.
- W2113862969 abstract "This study investigated the relationships between cyclosporin A (CsA) blood levels and episodes of renal allograft rejection and nephrotoxicity following renal transplantation, with the aim of establishing whether CsA profiles provided more useful information than single CsA blood levels in respect of these relationships.One hundred and sixty-two profiles were performed over 16 months in 40 patients and analysed retrospectively. Blood samples were taken at 0, 2, 4, 6 and 8 h after the morning CsA dose. Rejection episodes were diagnosed by renal biopsy and CsA nephrotoxicity by a fall in serum creatinine 1 week after a cut in CsA dose.The mean area under the curve (AUC) was lower for profiles performed at the time of rejection (3821 h.ng/ml) than that of a matched group of non-rejecting profiles (5479 h.ng/ml; P < 0.02). An AUC above 6400 h.ng/ml significantly discriminated rejection from non-rejection, whereas pre-dose and peak CsA concentrations did not have such discriminating cut-off values. A comparison of CsA-toxic and non-toxic profiles showed that there were no significant differences between mean CsA concentrations nor between the mean AUCs of these groups.We conclude that basing CsA dosing on CsA profiles could help to avoid some early episodes of rejection without increasing the risk of nephrotoxicity." @default.
- W2113862969 created "2016-06-24" @default.
- W2113862969 creator A5005376387 @default.
- W2113862969 creator A5005760414 @default.
- W2113862969 creator A5019533207 @default.
- W2113862969 creator A5079419790 @default.
- W2113862969 date "1996-08-01" @default.
- W2113862969 modified "2023-09-25" @default.
- W2113862969 title "Do cyclosporin proffles provide useful information in the management of renal transplant recipients?" @default.
- W2113862969 cites W1914914764 @default.
- W2113862969 cites W1981801952 @default.
- W2113862969 cites W1998631899 @default.
- W2113862969 cites W2001350377 @default.
- W2113862969 cites W2014323250 @default.
- W2113862969 cites W2031731525 @default.
- W2113862969 cites W2032208860 @default.
- W2113862969 cites W2044386504 @default.
- W2113862969 cites W2044457148 @default.
- W2113862969 cites W2050524102 @default.
- W2113862969 cites W2085415545 @default.
- W2113862969 cites W2091216349 @default.
- W2113862969 cites W2279429536 @default.
- W2113862969 cites W2315116432 @default.
- W2113862969 cites W2394525149 @default.
- W2113862969 cites W2406885572 @default.
- W2113862969 cites W2409599255 @default.
- W2113862969 cites W2411136220 @default.
- W2113862969 cites W2411766140 @default.
- W2113862969 cites W2424198397 @default.
- W2113862969 cites W2464987346 @default.
- W2113862969 cites W3121626055 @default.
- W2113862969 cites W3121821686 @default.
- W2113862969 cites W3149498517 @default.
- W2113862969 cites W3125242773 @default.
- W2113862969 doi "https://doi.org/10.1093/ndt/11.8.1597" @default.
- W2113862969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8856218" @default.
- W2113862969 hasPublicationYear "1996" @default.
- W2113862969 type Work @default.
- W2113862969 sameAs 2113862969 @default.
- W2113862969 citedByCount "8" @default.
- W2113862969 countsByYear W21138629692015 @default.
- W2113862969 crossrefType "journal-article" @default.
- W2113862969 hasAuthorship W2113862969A5005376387 @default.
- W2113862969 hasAuthorship W2113862969A5005760414 @default.
- W2113862969 hasAuthorship W2113862969A5019533207 @default.
- W2113862969 hasAuthorship W2113862969A5079419790 @default.
- W2113862969 hasConcept C126189478 @default.
- W2113862969 hasConcept C126322002 @default.
- W2113862969 hasConcept C126894567 @default.
- W2113862969 hasConcept C2777288759 @default.
- W2113862969 hasConcept C2779528694 @default.
- W2113862969 hasConcept C2780091579 @default.
- W2113862969 hasConcept C2780303639 @default.
- W2113862969 hasConcept C2780306776 @default.
- W2113862969 hasConcept C2911091166 @default.
- W2113862969 hasConcept C71924100 @default.
- W2113862969 hasConcept C76318530 @default.
- W2113862969 hasConcept C90924648 @default.
- W2113862969 hasConceptScore W2113862969C126189478 @default.
- W2113862969 hasConceptScore W2113862969C126322002 @default.
- W2113862969 hasConceptScore W2113862969C126894567 @default.
- W2113862969 hasConceptScore W2113862969C2777288759 @default.
- W2113862969 hasConceptScore W2113862969C2779528694 @default.
- W2113862969 hasConceptScore W2113862969C2780091579 @default.
- W2113862969 hasConceptScore W2113862969C2780303639 @default.
- W2113862969 hasConceptScore W2113862969C2780306776 @default.
- W2113862969 hasConceptScore W2113862969C2911091166 @default.
- W2113862969 hasConceptScore W2113862969C71924100 @default.
- W2113862969 hasConceptScore W2113862969C76318530 @default.
- W2113862969 hasConceptScore W2113862969C90924648 @default.
- W2113862969 hasIssue "8" @default.
- W2113862969 hasLocation W21138629691 @default.
- W2113862969 hasLocation W21138629692 @default.
- W2113862969 hasOpenAccess W2113862969 @default.
- W2113862969 hasPrimaryLocation W21138629691 @default.
- W2113862969 hasRelatedWork W1486584413 @default.
- W2113862969 hasRelatedWork W174477127 @default.
- W2113862969 hasRelatedWork W2061923809 @default.
- W2113862969 hasRelatedWork W2087086071 @default.
- W2113862969 hasRelatedWork W2117376546 @default.
- W2113862969 hasRelatedWork W2135058494 @default.
- W2113862969 hasRelatedWork W2149292431 @default.
- W2113862969 hasRelatedWork W2155342874 @default.
- W2113862969 hasRelatedWork W2397357675 @default.
- W2113862969 hasRelatedWork W4207024715 @default.
- W2113862969 hasVolume "11" @default.
- W2113862969 isParatext "false" @default.
- W2113862969 isRetracted "false" @default.
- W2113862969 magId "2113862969" @default.
- W2113862969 workType "article" @default.