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- W2113863168 abstract "The immunoregulatory protein T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates T-cell exhaustion and contributes to the suppression of immune responses in both viral infections and tumors. Tim-3 blockade reverses the exhausted phenotype of CD4+ and CD8+ T cells in several chronic diseases, including melanoma. Interestingly, natural killer (NK) cells constitutively express Tim-3; however, the role of Tim-3 in modulating the function of these innate effector cells remains unclear, particularly in human diseases. In this study, we compared the function of Tim-3 in NK cells from healthy donors and patients with metastatic melanoma. NK cells from the latter were functionally impaired/exhausted, and Tim-3 blockade reversed this exhausted phenotype. Moreover, Tim-3 expression levels were correlated with the stage of the disease and poor prognostic factors. These data indicate that Tim-3 can function as an NK-cell exhaustion marker in advanced melanoma and support the development of Tim-3-targeted therapies to restore antitumor immunity." @default.
- W2113863168 created "2016-06-24" @default.
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- W2113863168 date "2014-05-01" @default.
- W2113863168 modified "2023-10-17" @default.
- W2113863168 title "Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade" @default.
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- W2113863168 doi "https://doi.org/10.1158/2326-6066.cir-13-0171" @default.
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