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• W2113866657 abstract "1,5-Bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one (2) was isolated from Curcuma domestica as a curcumin (1)-related compound, which we named C5-curcumin. Intrigued by the potent antitumor activity of C5-curcumin (2)-related 1,5-bisaryl-1,4-pentadiene-3-ones [bis(arylmethylidene)acetones, termed C5-curcuminoids], we previously conducted a structure–activity relationship study of C5-curcuminoids and showed that highly active GO-Y030 [1,5-bis(3,5-bis(methoxymethoxy)phenyl)-1,4-pentadiene-3-one (4)] is the most promising antitumor compound. In this study, a panel of C5-curcuminoids based on GO-Y030, consisting of 30 new and 10 known compounds, was synthesized to elucidate in detail which moiety of GO-Y030 is significant for antitumor activity. The results confirmed that both the cross-conjugated dienone moiety and the 3,5-bis(methoxymethoxy) substituent are important for the antitumor activity." @default.
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• W2113866657 date "2015-08-24" @default.
• W2113866657 modified "2023-10-11" @default.
• W2113866657 title "Structure-Activity Relationships of the Antitumor C5-Curcuminoid GO-Y030" @default.
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• W2113866657 doi "https://doi.org/10.3390/molecules200815374" @default.
• W2113866657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6332050" @default.
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