FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W211388733> ?p ?o ?g. }

• W211388733 abstract "CRADD, also referred as RAIDD, is an adaptor protein that could interact with both caspase 2 and RIP that can promote apoptosis once activated. HDAC inhibitors are promising anti-cancer agents by inducing apoptosis of various cancer cells. In this study, we found that CRADD was induced by TSA (trichostatin A) to activate caspase 2-dependent apoptosis. CRADD was downregulated in gastric cancer and the restoration of its expression suppressed the viability of gastric cancer cells. HDAC1 was responsible for its downregulation in gastric cancer since HDAC1 siRNA upregulated CRADD expression and HDAC1 directly bound to the promoter of CRADD. Therefore, the high expression of HDAC1 can downregulate CRADD to confer gastric cancer cells the resistance to caspase 2-dependent apoptosis. HDAC inhibitors, potential anti-cancer drugs under investigation, can promote caspase 2-dependent apoptosis by inducing the expression of CRADD." @default.
• W211388733 created "2016-06-24" @default.
• W211388733 creator A5009875459 @default.
• W211388733 creator A5015591977 @default.
• W211388733 creator A5017427697 @default.
• W211388733 creator A5019751798 @default.
• W211388733 creator A5078313825 @default.
• W211388733 creator A5078812361 @default.
• W211388733 date "2014-01-01" @default.
• W211388733 modified "2023-09-22" @default.
• W211388733 title "Regulation of CRADD-caspase 2 cascade by histone deacetylase 1 in gastric cancer." @default.
• W211388733 cites W154704142 @default.
• W211388733 cites W1548032865 @default.
• W211388733 cites W1656544709 @default.
• W211388733 cites W1896195135 @default.
• W211388733 cites W1978259246 @default.
• W211388733 cites W1981944929 @default.
• W211388733 cites W2002503549 @default.
• W211388733 cites W2008515134 @default.
• W211388733 cites W2016724097 @default.
• W211388733 cites W2021245078 @default.
• W211388733 cites W2022285476 @default.
• W211388733 cites W2025128734 @default.
• W211388733 cites W2026969191 @default.
• W211388733 cites W2027741880 @default.
• W211388733 cites W2031239153 @default.
• W211388733 cites W2038212272 @default.
• W211388733 cites W2053733372 @default.
• W211388733 cites W2064593724 @default.
• W211388733 cites W2077196713 @default.
• W211388733 cites W2080666241 @default.
• W211388733 cites W2084620432 @default.
• W211388733 cites W2086078758 @default.
• W211388733 cites W2089023118 @default.
• W211388733 cites W2089082314 @default.
• W211388733 cites W2097005995 @default.
• W211388733 cites W2102611193 @default.
• W211388733 cites W2102650381 @default.
• W211388733 cites W2126532720 @default.
• W211388733 cites W2133388311 @default.
• W211388733 cites W2143658931 @default.
• W211388733 cites W2151124060 @default.
• W211388733 cites W2165430326 @default.
• W211388733 cites W2168829711 @default.
• W211388733 cites W2169914552 @default.
• W211388733 cites W26190000 @default.
• W211388733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4212928" @default.
• W211388733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25360218" @default.
• W211388733 hasPublicationYear "2014" @default.
• W211388733 type Work @default.
• W211388733 sameAs 211388733 @default.
• W211388733 citedByCount "4" @default.
• W211388733 countsByYear W2113887332016 @default.
• W211388733 countsByYear W2113887332019 @default.
• W211388733 countsByYear W2113887332021 @default.
• W211388733 countsByYear W2113887332022 @default.
• W211388733 crossrefType "journal-article" @default.
• W211388733 hasAuthorship W211388733A5009875459 @default.
• W211388733 hasAuthorship W211388733A5015591977 @default.
• W211388733 hasAuthorship W211388733A5017427697 @default.
• W211388733 hasAuthorship W211388733A5019751798 @default.
• W211388733 hasAuthorship W211388733A5078313825 @default.
• W211388733 hasAuthorship W211388733A5078812361 @default.
• W211388733 hasConcept C104317684 @default.
• W211388733 hasConcept C121608353 @default.
• W211388733 hasConcept C127561419 @default.
• W211388733 hasConcept C185592680 @default.
• W211388733 hasConcept C190283241 @default.
• W211388733 hasConcept C2777865847 @default.
• W211388733 hasConcept C2778305200 @default.
• W211388733 hasConcept C502942594 @default.
• W211388733 hasConcept C54355233 @default.
• W211388733 hasConcept C55493867 @default.
• W211388733 hasConcept C64927066 @default.
• W211388733 hasConcept C85240754 @default.
• W211388733 hasConcept C86803240 @default.
• W211388733 hasConcept C96232424 @default.
• W211388733 hasConceptScore W211388733C104317684 @default.
• W211388733 hasConceptScore W211388733C121608353 @default.
• W211388733 hasConceptScore W211388733C127561419 @default.
• W211388733 hasConceptScore W211388733C185592680 @default.
• W211388733 hasConceptScore W211388733C190283241 @default.
• W211388733 hasConceptScore W211388733C2777865847 @default.
• W211388733 hasConceptScore W211388733C2778305200 @default.
• W211388733 hasConceptScore W211388733C502942594 @default.
• W211388733 hasConceptScore W211388733C54355233 @default.
• W211388733 hasConceptScore W211388733C55493867 @default.
• W211388733 hasConceptScore W211388733C64927066 @default.
• W211388733 hasConceptScore W211388733C85240754 @default.
• W211388733 hasConceptScore W211388733C86803240 @default.
• W211388733 hasConceptScore W211388733C96232424 @default.
• W211388733 hasLocation W2113887331 @default.
• W211388733 hasOpenAccess W211388733 @default.
• W211388733 hasPrimaryLocation W2113887331 @default.
• W211388733 hasRelatedWork W1500005278 @default.
• W211388733 hasRelatedWork W1986429987 @default.
• W211388733 hasRelatedWork W1998780829 @default.
• W211388733 hasRelatedWork W1998876947 @default.
• W211388733 hasRelatedWork W1999578065 @default.
• W211388733 hasRelatedWork W2035255389 @default.

• next