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• W2113906902 abstract "Mast cell degranulation is important in the pathogenesis of anaphylaxis and allergic disorders. Many animal venoms contain components that can induce mast cell degranulation, and this has been thought to contribute to the pathology and mortality caused by envenomation. However, we recently reported evidence that mast cells can enhance the resistance of mice to the venoms of certain snakes and that mouse mast cell-derived carboxypeptidase A3 (CPA3) can contribute to this effect. Here, we investigated whether mast cells can enhance resistance to the venom of the Gila monster, a toxic component of that venom (helodermin), and the structurally similar mammalian peptide, vasoactive intestinal polypeptide (VIP). Using 2 types of mast cell-deficient mice, as well as mice selectively lacking CPA3 activity or the chymase mouse mast cell protease-4 (MCPT4), we found that mast cells and MCPT4, which can degrade helodermin, can enhance host resistance to the toxicity of Gila monster venom. Mast cells and MCPT4 also can limit the toxicity associated with high concentrations of VIP and can reduce the morbidity and mortality induced by venoms from 2 species of scorpions. Our findings support the notion that mast cells can enhance innate defense by degradation of diverse animal toxins and that release of MCPT4, in addition to CPA3, can contribute to this mast cell function." @default.
• W2113906902 created "2016-06-24" @default.
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• W2113906902 date "2011-10-03" @default.
• W2113906902 modified "2023-10-17" @default.
• W2113906902 title "Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice" @default.
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• W2113906902 cites W1575520676 @default.
• W2113906902 cites W1583886451 @default.
• W2113906902 cites W1586061801 @default.
• W2113906902 cites W1591702766 @default.
• W2113906902 cites W1601094160 @default.
• W2113906902 cites W1603013239 @default.
• W2113906902 cites W1963546358 @default.
• W2113906902 cites W1966214201 @default.
• W2113906902 cites W1972447401 @default.
• W2113906902 cites W1973035303 @default.
• W2113906902 cites W1975744071 @default.
• W2113906902 cites W1976583941 @default.
• W2113906902 cites W1982780648 @default.
• W2113906902 cites W1982814765 @default.
• W2113906902 cites W1986738891 @default.
• W2113906902 cites W1987585793 @default.
• W2113906902 cites W1988377631 @default.
• W2113906902 cites W1992027769 @default.
• W2113906902 cites W1992363777 @default.
• W2113906902 cites W1996248701 @default.
• W2113906902 cites W1998930245 @default.
• W2113906902 cites W2003763178 @default.
• W2113906902 cites W2003994249 @default.
• W2113906902 cites W2006934195 @default.
• W2113906902 cites W2008480577 @default.
• W2113906902 cites W2008786689 @default.
• W2113906902 cites W2009408112 @default.
• W2113906902 cites W2011594346 @default.
• W2113906902 cites W2019918273 @default.
• W2113906902 cites W2021709625 @default.
• W2113906902 cites W2024697593 @default.
• W2113906902 cites W2025309567 @default.
• W2113906902 cites W2025596690 @default.
• W2113906902 cites W2028095092 @default.
• W2113906902 cites W2029830646 @default.
• W2113906902 cites W2033964949 @default.
• W2113906902 cites W2034203371 @default.
• W2113906902 cites W2035958379 @default.
• W2113906902 cites W2043912268 @default.
• W2113906902 cites W2043992563 @default.
• W2113906902 cites W2048338013 @default.
• W2113906902 cites W2048339104 @default.
• W2113906902 cites W2064180188 @default.
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• W2113906902 cites W2069889708 @default.
• W2113906902 cites W2070107659 @default.
• W2113906902 cites W2070179230 @default.
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• W2113906902 cites W2085409130 @default.
• W2113906902 cites W2089785871 @default.
• W2113906902 cites W2090657368 @default.
• W2113906902 cites W2095142211 @default.
• W2113906902 cites W2098509280 @default.
• W2113906902 cites W2101494997 @default.
• W2113906902 cites W2107153285 @default.
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• W2113906902 cites W2137373326 @default.
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• W2113906902 doi "https://doi.org/10.1172/jci46139" @default.
• W2113906902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3195461" @default.
• W2113906902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21926462" @default.
• W2113906902 hasPublicationYear "2011" @default.
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