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• W2113916248 endingPage "e22671" @default.
• W2113916248 startingPage "e22671" @default.
• W2113916248 abstract "Cellular DExD/H-box RNA-helicases perform essential functions during mRNA biogenesis. The closely related human proteins UAP56 and URH49 are members of this protein family and play an essential role for cellular mRNA export by recruiting the adaptor protein REF to spliced and unspliced mRNAs. In order to gain insight into their mode of action, we aimed to characterize these RNA-helicases in more detail. Here, we demonstrate that UAP56 and URH49 exhibit an intrinsic CRM1-independent nucleocytoplasmic shuttling activity. Extensive mapping studies identified distinct regions within UAP56 or URH49 required for (i) intranuclear localization (UAP56 aa81-381) and (ii) interaction with REF (UAP56 aa51-428). Moreover, the region conferring nucleocytoplasmic shuttling activity was mapped to the C-terminus of UAP56, comprising the amino acids 195-428. Interestingly, this region coincides with a domain within Uap56p of S. pombe that has been reported to be required for both Rae1p-interaction and nucleocytoplasmic shuttling. However, in contrast to this finding we report that human UAP56 shuttles independently from Rae1. In summary, our results reveal nucleocytoplasmic shuttling as a conserved feature of yeast and human UAP56, while their export receptor seems to have diverged during evolution." @default.
• W2113916248 created "2016-06-24" @default.
• W2113916248 creator A5004174742 @default.
• W2113916248 creator A5008645048 @default.
• W2113916248 creator A5031660301 @default.
• W2113916248 creator A5087862950 @default.
• W2113916248 date "2011-07-22" @default.
• W2113916248 modified "2023-10-18" @default.
• W2113916248 title "The Cellular DExD/H-Box RNA-Helicases UAP56 and URH49 Exhibit a CRM1-Independent Nucleocytoplasmic Shuttling Activity" @default.
• W2113916248 cites W1508541438 @default.
• W2113916248 cites W1562998360 @default.
• W2113916248 cites W1949569431 @default.
• W2113916248 cites W1966735041 @default.
• W2113916248 cites W1969312379 @default.
• W2113916248 cites W1974905046 @default.
• W2113916248 cites W1974966784 @default.
• W2113916248 cites W1980064429 @default.
• W2113916248 cites W1981332748 @default.
• W2113916248 cites W1983994417 @default.
• W2113916248 cites W1986313893 @default.
• W2113916248 cites W1987560539 @default.
• W2113916248 cites W1991344629 @default.
• W2113916248 cites W1992950392 @default.
• W2113916248 cites W1993374643 @default.
• W2113916248 cites W1995842607 @default.
• W2113916248 cites W1997250436 @default.
• W2113916248 cites W1997961264 @default.
• W2113916248 cites W2000734570 @default.
• W2113916248 cites W2004988279 @default.
• W2113916248 cites W2005855998 @default.
• W2113916248 cites W2006484928 @default.
• W2113916248 cites W2007563522 @default.
• W2113916248 cites W2009183437 @default.
• W2113916248 cites W2009207482 @default.
• W2113916248 cites W2012538868 @default.
• W2113916248 cites W2019860831 @default.
• W2113916248 cites W2021026930 @default.
• W2113916248 cites W2022546135 @default.
• W2113916248 cites W2025232919 @default.
• W2113916248 cites W2028786347 @default.
• W2113916248 cites W2031164737 @default.
• W2113916248 cites W2032785100 @default.
• W2113916248 cites W2045845081 @default.
• W2113916248 cites W2049314528 @default.
• W2113916248 cites W2061845887 @default.
• W2113916248 cites W2066043643 @default.
• W2113916248 cites W2070510657 @default.
• W2113916248 cites W2072449263 @default.
• W2113916248 cites W2076054312 @default.
• W2113916248 cites W2076831072 @default.
• W2113916248 cites W2079147110 @default.
• W2113916248 cites W2079411454 @default.
• W2113916248 cites W2083340704 @default.
• W2113916248 cites W2085192863 @default.
• W2113916248 cites W2086660631 @default.
• W2113916248 cites W2087194879 @default.
• W2113916248 cites W2101543197 @default.
• W2113916248 cites W2102005607 @default.
• W2113916248 cites W2104554283 @default.
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• W2113916248 cites W2125786017 @default.
• W2113916248 cites W2126409874 @default.
• W2113916248 cites W2138647063 @default.
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• W2113916248 cites W2155085170 @default.
• W2113916248 cites W2155127403 @default.
• W2113916248 cites W2155915917 @default.
• W2113916248 cites W2163765191 @default.
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• W2113916248 doi "https://doi.org/10.1371/journal.pone.0022671" @default.
• W2113916248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3142171" @default.
• W2113916248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21799930" @default.
• W2113916248 hasPublicationYear "2011" @default.
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