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• W2113919970 abstract "<b>Objective: </b> To determine whether pretreatment markers of coagulation and fibrinolysis are related to recanalization and functional outcome. <b>Methods: </b> The authors included patients treated with IV rt-PA with occlusion on baseline transcranial Doppler (Thrombolysis in Brain Ischemia [TIBI] criteria) in whom recanalization within 6 hours was monitored. At baseline, the authors recorded data about demographics, vascular risk factors, the NIH Stroke Scale (NIHSS) score, early CT signs, etiology, blood glucose, and time to rt-PA. The authors also measured plasmatic markers of coagulation (fibrinogen, prothrombin fragments 1 + 2, Factor XIII, Factor VII) and fibrinolysis (α₂-antiplasmin, Plasminogen Activator Inhibitor, Functional Thrombin Activatable Fibrinolysis Inhibitor [fTAFI]). A favorable outcome was defined as a modified Rankin score < 2 at 3 months. <b>Results: </b> The authors studied 63 patients with a mean age of 67.3 ± 12.5 years. The median NIHSS score was 16. Patients who recanalized had lower concentrations of α₂-antiplasmin (87.5 ± 18% vs 96.5 ± 12.5%, <i>p</i> = 0.023) and fTAFI (91.7 ± 26.7% vs 104.4 ± 21%, <i>p</i> = 0.039). A multivariant logistic regression analysis showed that the level of α₂-antiplasmin was the only predictive variable of recanalization (OR 0.95, 95% CI 0.91, 0.99, <i>p</i> = 0.038), while the NIHSS score was the only predictive variable of functional outcome (OR 0.81, 95% CI 0.72, 0.92, <i>p</i> = 0.001). <b>Conclusion: </b> Baseline levels of α₂-antiplasmin were predictive of recanalization but were not related to the long-term outcome in patients treated with rt-PA within the first 3 hours." @default.
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• W2113919970 date "2005-08-08" @default.
• W2113919970 modified "2023-10-18" @default.
• W2113919970 title "Hemostatic markers of recanalization in patients with ischemic stroke treated with rt-PA" @default.
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• W2113919970 doi "https://doi.org/10.1212/01.wnl.0000171704.50395.ba" @default.
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