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- W2113968751 abstract "In humans, steroid 5α-reductase is involved in the development of benign prostatic hyperplasia (BPH). We tested the steroid 5α-reductase inhibitory activity of the 70% acetone extract of woody plants. The tannin polymer prepared from the 70% acetone extract showed the highest steroid 5α-reductase inhibitory activity. Furthermore, the steroid 5α-reductase inhibitory activity of tannins was not affected by the addition of superoxide dismutase or catalase. It was concluded that the steroid 5α-reductase inhibitory activity of condensed tannin was caused by binding to the steroid 5α-reductase, rather than from the peroxide/superoxide produced by tannins. The tannins, prepared from tree barks, with potential for steroid 5α-reductase inhibitory activity might be advantageous in therapy for steroid 5α-reductase diseases such as BPH or prostate cancer." @default.
- W2113968751 created "2016-06-24" @default.
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- W2113968751 date "2008-02-01" @default.
- W2113968751 modified "2023-10-16" @default.
- W2113968751 title "Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants" @default.
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- W2113968751 doi "https://doi.org/10.1007/s10086-007-0905-9" @default.
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