FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113977319> ?p ?o ?g. }

• W2113977319 endingPage "229" @default.
• W2113977319 startingPage "223" @default.
• W2113977319 abstract "Inhibins are gonadal glycoprotein hormones whose main endocrine function is to inhibit pituitary FSH secretion. In addition to testes and ovaries, other steroid-producing organs are sites of inhibin alpha subunit expression. To study the role of inhibins in human adrenal gland, we screened a panel of 150 adrenals (10 normal adrenals, 25 adrenocortical hyperplasias, 65 adrenocortical adenomas, 30 adrenocortical carcinomas and 20 phaeochromocytomas) for inhibin alpha expression. mRNA levels of inhibin alpha subunit were studied in 57 samples and all tissues were stained immunohistochemically with an inhibin alpha subunit-specific antibody. Inhibin alpha mRNA was detected in all adrenocortical tissues. Virilizing adenomas possessed a 10-fold higher median inhibin alpha mRNA expression than did normal adrenals. Bilaterally and nodularly hyperplastic adrenals and other than virilizing adrenocortical tumours had their median inhibin alpha mRNA levels close to those of normal adrenals. Immunohistochemically, inhibin alpha subunit was detectable in all normal and hyperplastic adrenals, as well as in 73% of the adrenocortical tumours. However, the percentage of inhibin alpha-positive cells varied greatly in different tumour types. The median percentage of positive cells was 10 in non-functional and Conn's adenomas, 30 in Cushing's adenomas and 75 in virilizing adenomas. In malignant adrenocortical tumours the median percentage of inhibin alpha-immunopositive cells was 20 in non-functional carcinomas, 30 in Conn's carcinomas, 65 in Cushing's carcinomas and 75 in virilizing carcinomas. All phaeochromocytomas were negative for inhibin alpha subunit both at the mRNA level and immunohistochemically. Our data show that inhibin alpha subunit is highly expressed in both normal and neoplastic androgen-producing adrenocortical cells, with less expression in cortisol-producing and hardly any in aldosterone-producing cells. This suggests a specific role for inhibins in the regulation of adrenal androgen production. We did not find any significant difference in inhibin alpha expression between benign and malignant adrenocortical tumours. Thus inhibin alpha gene does not seem to have a tumour suppressor role in human adrenal cortex." @default.
• W2113977319 created "2016-06-24" @default.
• W2113977319 creator A5031942948 @default.
• W2113977319 creator A5061963131 @default.
• W2113977319 creator A5063720091 @default.
• W2113977319 creator A5065057881 @default.
• W2113977319 creator A5069256699 @default.
• W2113977319 creator A5074924102 @default.
• W2113977319 creator A5081318312 @default.
• W2113977319 date "2000-05-01" @default.
• W2113977319 modified "2023-10-01" @default.
• W2113977319 title "Expression of inhibin alpha in adrenocortical tumours reflects the hormonal status of the neoplasm" @default.
• W2113977319 cites W144216034 @default.
• W2113977319 cites W1965871014 @default.
• W2113977319 cites W1967536782 @default.
• W2113977319 cites W1976265973 @default.
• W2113977319 cites W1981881514 @default.
• W2113977319 cites W1989726231 @default.
• W2113977319 cites W2007227919 @default.
• W2113977319 cites W2008963508 @default.
• W2113977319 cites W2023370041 @default.
• W2113977319 cites W2029694860 @default.
• W2113977319 cites W2035066075 @default.
• W2113977319 cites W2039836243 @default.
• W2113977319 cites W2044251091 @default.
• W2113977319 cites W2057980349 @default.
• W2113977319 cites W2060333964 @default.
• W2113977319 cites W2064224644 @default.
• W2113977319 cites W2072346297 @default.
• W2113977319 cites W2080579912 @default.
• W2113977319 cites W2082351836 @default.
• W2113977319 cites W2117995676 @default.
• W2113977319 cites W2141609466 @default.
• W2113977319 cites W2147927793 @default.
• W2113977319 cites W2152295819 @default.
• W2113977319 cites W2161919661 @default.
• W2113977319 cites W2319220638 @default.
• W2113977319 cites W2321504557 @default.
• W2113977319 cites W2469869745 @default.
• W2113977319 cites W64495566 @default.
• W2113977319 doi "https://doi.org/10.1677/joe.0.1650223" @default.
• W2113977319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10810286" @default.
• W2113977319 hasPublicationYear "2000" @default.
• W2113977319 type Work @default.
• W2113977319 sameAs 2113977319 @default.
• W2113977319 citedByCount "72" @default.
• W2113977319 countsByYear W21139773192012 @default.
• W2113977319 countsByYear W21139773192013 @default.
• W2113977319 countsByYear W21139773192014 @default.
• W2113977319 countsByYear W21139773192015 @default.
• W2113977319 countsByYear W21139773192016 @default.
• W2113977319 countsByYear W21139773192017 @default.
• W2113977319 countsByYear W21139773192018 @default.
• W2113977319 countsByYear W21139773192019 @default.
• W2113977319 countsByYear W21139773192020 @default.
• W2113977319 countsByYear W21139773192021 @default.
• W2113977319 countsByYear W21139773192022 @default.
• W2113977319 countsByYear W21139773192023 @default.
• W2113977319 crossrefType "journal-article" @default.
• W2113977319 hasAuthorship W2113977319A5031942948 @default.
• W2113977319 hasAuthorship W2113977319A5061963131 @default.
• W2113977319 hasAuthorship W2113977319A5063720091 @default.
• W2113977319 hasAuthorship W2113977319A5065057881 @default.
• W2113977319 hasAuthorship W2113977319A5069256699 @default.
• W2113977319 hasAuthorship W2113977319A5074924102 @default.
• W2113977319 hasAuthorship W2113977319A5081318312 @default.
• W2113977319 hasBestOaLocation W21139773191 @default.
• W2113977319 hasConcept C104292427 @default.
• W2113977319 hasConcept C104317684 @default.
• W2113977319 hasConcept C126322002 @default.
• W2113977319 hasConcept C134018914 @default.
• W2113977319 hasConcept C159110408 @default.
• W2113977319 hasConcept C2775944032 @default.
• W2113977319 hasConcept C2781399356 @default.
• W2113977319 hasConcept C49453240 @default.
• W2113977319 hasConcept C55493867 @default.
• W2113977319 hasConcept C64943373 @default.
• W2113977319 hasConcept C71315377 @default.
• W2113977319 hasConcept C71924100 @default.
• W2113977319 hasConcept C83730767 @default.
• W2113977319 hasConcept C86803240 @default.
• W2113977319 hasConceptScore W2113977319C104292427 @default.
• W2113977319 hasConceptScore W2113977319C104317684 @default.
• W2113977319 hasConceptScore W2113977319C126322002 @default.
• W2113977319 hasConceptScore W2113977319C134018914 @default.
• W2113977319 hasConceptScore W2113977319C159110408 @default.
• W2113977319 hasConceptScore W2113977319C2775944032 @default.
• W2113977319 hasConceptScore W2113977319C2781399356 @default.
• W2113977319 hasConceptScore W2113977319C49453240 @default.
• W2113977319 hasConceptScore W2113977319C55493867 @default.
• W2113977319 hasConceptScore W2113977319C64943373 @default.
• W2113977319 hasConceptScore W2113977319C71315377 @default.
• W2113977319 hasConceptScore W2113977319C71924100 @default.
• W2113977319 hasConceptScore W2113977319C83730767 @default.
• W2113977319 hasConceptScore W2113977319C86803240 @default.
• W2113977319 hasIssue "2" @default.
• W2113977319 hasLocation W21139773191 @default.
• W2113977319 hasLocation W21139773192 @default.

• next