FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113979191> ?p ?o ?g. }

• W2113979191 endingPage "234" @default.
• W2113979191 startingPage "227" @default.
• W2113979191 abstract "Bullous pemphigoid (BP) is the most common autoimmune blistering disease in older people, and is associated with significant morbidity and mortality. Oral corticosteroids are usually effective but the side‐effects are thought to contribute to the high morbidity and mortality rate. Treatment with oral tetracyclines may be effective but high‐quality, randomized controlled trials (RCTs) are needed to confirm this. To compare the effectiveness and safety of two strategies for treating BP. This is a two‐arm, parallel group, 52‐week RCT comparing doxycycline with prednisolone for initial treatment of BP. Dose is fixed for the initial 6 weeks of treatment (doxycycline 200 mg daily; prednisolone 0·5 mg kg−1 daily), after which it can be adjusted according to need. A total of 256 patients with BP will be recruited in the U.K. and Germany. The primary outcomes are: (i) effectiveness (assessor‐blinded blister count at 6 weeks) and (ii) safety [proportion of patients experiencing ≥ grade 3 adverse events (i.e. severe, life: threatening or fatal) related to trial medication during the year of follow‐up]. Primary effectiveness analysis will be an assessment of whether doxycycline can be considered noninferior to prednisolone after 6 weeks of treatment. Primary safety analysis is a superiority analysis at 12 months. Secondary outcomes include longer‐term assessment of effectiveness, relapse rates, the proportion of patients experiencing any grade of adverse events related to treatment, quality of life and cost‐effectiveness. The trial will provide good evidence for whether the strategy of starting BP treatment with doxycycline is a useful alternative to prednisolone." @default.
• W2113979191 created "2016-06-24" @default.
• W2113979191 creator A5020273160 @default.
• W2113979191 creator A5026581021 @default.
• W2113979191 creator A5033907428 @default.
• W2113979191 creator A5039486126 @default.
• W2113979191 creator A5049764403 @default.
• W2113979191 creator A5053611545 @default.
• W2113979191 creator A5059227210 @default.
• W2113979191 creator A5062598432 @default.
• W2113979191 creator A5070207982 @default.
• W2113979191 date "2015-05-26" @default.
• W2113979191 modified "2023-09-25" @default.
• W2113979191 title "A randomized controlled trial to compare the safety and effectiveness of doxycycline (200 mg daily) with oral prednisolone (0·5 mg kg−1 daily) for initial treatment of bullous pemphigoid: a protocol for the Bullous Pemphigoid Steroids and Tetracyclines (B" @default.
• W2113979191 cites W1976125415 @default.
• W2113979191 cites W2006958091 @default.
• W2113979191 cites W2007239126 @default.
• W2113979191 cites W2018479414 @default.
• W2113979191 cites W2029273508 @default.
• W2113979191 cites W2054414140 @default.
• W2113979191 cites W2054438253 @default.
• W2113979191 cites W2061413735 @default.
• W2113979191 cites W2072785143 @default.
• W2113979191 cites W2076982024 @default.
• W2113979191 cites W2085109894 @default.
• W2113979191 cites W2111620283 @default.
• W2113979191 cites W2113264185 @default.
• W2113979191 cites W2123531321 @default.
• W2113979191 cites W2134091132 @default.
• W2113979191 cites W2142982349 @default.
• W2113979191 cites W2162070463 @default.
• W2113979191 cites W2187935508 @default.
• W2113979191 cites W4211003831 @default.
• W2113979191 cites W2015453705 @default.
• W2113979191 doi "https://doi.org/10.1111/bjd.13729" @default.
• W2113979191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25683592" @default.
• W2113979191 hasPublicationYear "2015" @default.
• W2113979191 type Work @default.
• W2113979191 sameAs 2113979191 @default.
• W2113979191 citedByCount "18" @default.
• W2113979191 countsByYear W21139791912015 @default.
• W2113979191 countsByYear W21139791912016 @default.
• W2113979191 countsByYear W21139791912017 @default.
• W2113979191 countsByYear W21139791912018 @default.
• W2113979191 countsByYear W21139791912021 @default.
• W2113979191 countsByYear W21139791912023 @default.
• W2113979191 crossrefType "journal-article" @default.
• W2113979191 hasAuthorship W2113979191A5020273160 @default.
• W2113979191 hasAuthorship W2113979191A5026581021 @default.
• W2113979191 hasAuthorship W2113979191A5033907428 @default.
• W2113979191 hasAuthorship W2113979191A5039486126 @default.
• W2113979191 hasAuthorship W2113979191A5049764403 @default.
• W2113979191 hasAuthorship W2113979191A5053611545 @default.
• W2113979191 hasAuthorship W2113979191A5059227210 @default.
• W2113979191 hasAuthorship W2113979191A5062598432 @default.
• W2113979191 hasAuthorship W2113979191A5070207982 @default.
• W2113979191 hasConcept C126322002 @default.
• W2113979191 hasConcept C141071460 @default.
• W2113979191 hasConcept C159110408 @default.
• W2113979191 hasConcept C159654299 @default.
• W2113979191 hasConcept C168563851 @default.
• W2113979191 hasConcept C197934379 @default.
• W2113979191 hasConcept C203014093 @default.
• W2113979191 hasConcept C2776715498 @default.
• W2113979191 hasConcept C2777179404 @default.
• W2113979191 hasConcept C2778075117 @default.
• W2113979191 hasConcept C2779252107 @default.
• W2113979191 hasConcept C2779951463 @default.
• W2113979191 hasConcept C501593827 @default.
• W2113979191 hasConcept C71924100 @default.
• W2113979191 hasConcept C86803240 @default.
• W2113979191 hasConcept C89423630 @default.
• W2113979191 hasConceptScore W2113979191C126322002 @default.
• W2113979191 hasConceptScore W2113979191C141071460 @default.
• W2113979191 hasConceptScore W2113979191C159110408 @default.
• W2113979191 hasConceptScore W2113979191C159654299 @default.
• W2113979191 hasConceptScore W2113979191C168563851 @default.
• W2113979191 hasConceptScore W2113979191C197934379 @default.
• W2113979191 hasConceptScore W2113979191C203014093 @default.
• W2113979191 hasConceptScore W2113979191C2776715498 @default.
• W2113979191 hasConceptScore W2113979191C2777179404 @default.
• W2113979191 hasConceptScore W2113979191C2778075117 @default.
• W2113979191 hasConceptScore W2113979191C2779252107 @default.
• W2113979191 hasConceptScore W2113979191C2779951463 @default.
• W2113979191 hasConceptScore W2113979191C501593827 @default.
• W2113979191 hasConceptScore W2113979191C71924100 @default.
• W2113979191 hasConceptScore W2113979191C86803240 @default.
• W2113979191 hasConceptScore W2113979191C89423630 @default.
• W2113979191 hasIssue "1" @default.
• W2113979191 hasLocation W21139791911 @default.
• W2113979191 hasLocation W21139791912 @default.
• W2113979191 hasOpenAccess W2113979191 @default.
• W2113979191 hasPrimaryLocation W21139791911 @default.
• W2113979191 hasRelatedWork W2113979191 @default.
• W2113979191 hasRelatedWork W2575603189 @default.
• W2113979191 hasRelatedWork W2746490343 @default.
• W2113979191 hasRelatedWork W2756905600 @default.
• W2113979191 hasRelatedWork W2792078413 @default.

• next