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- W2113990919 endingPage "1992" @default.
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- W2113990919 abstract "ABSTRACT Human immunodeficiency virus type 1 (HIV-1) is able to evade the host cytotoxic T-lymphocyte (CTL) response through a variety of escape avenues. Epitopes that are presented to CTLs are first processed in the presenting cell in several steps, including proteasomal cleavage, transport to the endoplasmic reticulum, binding by the HLA molecule, and finally presentation to the T-cell receptor. An understanding of the potential of the virus to escape CTL responses can aid in designing an effective vaccine. To investigate such a potential, we analyzed HIV-1 gag from 468 HIV-1-positive Kenyan women by using several bioinformatic approaches that allowed the identification of positively selected amino acids in the HIV-1 gag region and study of the effects that these mutations could have on the various stages of antigen processing. Correlations between positively selected residues and mean CD4 counts also allowed study of the effect of mutation on HIV disease progression. A number of mutations that could create or destroy proteasomal cleavage sites or reduce binding affinity of the transport antigen processing protein, effectively hindering epitope presentation, were identified. Many mutations correlated with the presence of specific HLA alleles and with lower or higher CD4 counts. For instance, the mutation V190I in subtype A1-infected individuals is associated with HLA-B*5802 ( P = 4.73 × 10 −4 ), a rapid-progression allele according to other studies, and also to a decreased mean CD4 count ( P = 0.019). Thus, V190I is a possible HLA escape mutant. This method classifies many positively selected mutations across the entire gag region according to their potential for immune escape and their effect on disease progression." @default.
- W2113990919 created "2016-06-24" @default.
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- W2113990919 date "2008-02-15" @default.
- W2113990919 modified "2023-09-27" @default.
- W2113990919 title "An Integrative Bioinformatic Approach for Studying Escape Mutations in Human Immunodeficiency Virus Type 1 <i>gag</i> in the Pumwani Sex Worker Cohort" @default.
- W2113990919 cites W1516342533 @default.
- W2113990919 cites W1547922948 @default.
- W2113990919 cites W1575634439 @default.
- W2113990919 cites W1608151378 @default.
- W2113990919 cites W1907564416 @default.
- W2113990919 cites W1932388426 @default.
- W2113990919 cites W1965569618 @default.
- W2113990919 cites W1970572484 @default.
- W2113990919 cites W1978141733 @default.
- W2113990919 cites W1978835331 @default.
- W2113990919 cites W1981696286 @default.
- W2113990919 cites W1982997055 @default.
- W2113990919 cites W1992039355 @default.
- W2113990919 cites W1993452562 @default.
- W2113990919 cites W1993877052 @default.
- W2113990919 cites W1995875735 @default.
- W2113990919 cites W1996888701 @default.
- W2113990919 cites W1998670002 @default.
- W2113990919 cites W2006694708 @default.
- W2113990919 cites W2010951564 @default.
- W2113990919 cites W2027504999 @default.
- W2113990919 cites W2029353650 @default.
- W2113990919 cites W2029774129 @default.
- W2113990919 cites W2037415719 @default.
- W2113990919 cites W2038599188 @default.
- W2113990919 cites W2045043379 @default.
- W2113990919 cites W2045551237 @default.
- W2113990919 cites W2053695022 @default.
- W2113990919 cites W2056119728 @default.
- W2113990919 cites W2061714407 @default.
- W2113990919 cites W2067560365 @default.
- W2113990919 cites W2085355019 @default.
- W2113990919 cites W2087137589 @default.
- W2113990919 cites W2087484510 @default.
- W2113990919 cites W2088204382 @default.
- W2113990919 cites W2089968073 @default.
- W2113990919 cites W2090147323 @default.
- W2113990919 cites W2091216865 @default.
- W2113990919 cites W2092162393 @default.
- W2113990919 cites W2095983332 @default.
- W2113990919 cites W2097504226 @default.
- W2113990919 cites W2099149517 @default.
- W2113990919 cites W2101049386 @default.
- W2113990919 cites W2102159102 @default.
- W2113990919 cites W2105813980 @default.
- W2113990919 cites W2107755945 @default.
- W2113990919 cites W2108446353 @default.
- W2113990919 cites W2110211157 @default.
- W2113990919 cites W2112114954 @default.
- W2113990919 cites W2116631841 @default.
- W2113990919 cites W2117252247 @default.
- W2113990919 cites W2117333383 @default.
- W2113990919 cites W2121753315 @default.
- W2113990919 cites W2122405569 @default.
- W2113990919 cites W2123096807 @default.
- W2113990919 cites W2125586839 @default.
- W2113990919 cites W2126781708 @default.
- W2113990919 cites W2127771003 @default.
- W2113990919 cites W2135121171 @default.
- W2113990919 cites W2138829684 @default.
- W2113990919 cites W2142316620 @default.
- W2113990919 cites W2142774061 @default.
- W2113990919 cites W2142831360 @default.
- W2113990919 cites W2143210482 @default.
- W2113990919 cites W2144239607 @default.
- W2113990919 cites W2146291971 @default.
- W2113990919 cites W2146396346 @default.
- W2113990919 cites W2147134928 @default.
- W2113990919 cites W2147710356 @default.
- W2113990919 cites W2151651155 @default.
- W2113990919 cites W2155786171 @default.
- W2113990919 cites W2157654243 @default.
- W2113990919 cites W2161083183 @default.
- W2113990919 cites W2165977771 @default.
- W2113990919 cites W2166374206 @default.
- W2113990919 cites W2169600303 @default.
- W2113990919 cites W2169629503 @default.
- W2113990919 cites W2169847792 @default.
- W2113990919 doi "https://doi.org/10.1128/jvi.02742-06" @default.
- W2113990919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2258736" @default.