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• W2113991587 abstract "The molecular mechanisms underlying pressure-induced protein denaturation can be analyzed based on the pressure-dependent differences in the apparent volume occupied by amino acids inside the protein and when they are exposed to water in an unfolded conformation. We present here an analysis for the peptide group and the 20 naturally occurring amino acid side chains based on volumetric parameters for the amino acids in the interior of the native state, the micelle-like interior of the pressure-induced denatured state, and the unfolded conformation modeled by N-acetyl amino acid amides. The transfer of peptide groups from the protein interior to water becomes increasingly favorable as pressure increases. Thus, solvation of peptide groups represents a major driving force in pressure-induced protein denaturation. Polar side chains do not appear to exhibit significant pressure-dependent changes in their preference for the protein interior or solvent. The transfer of nonpolar side chains from the protein interior to water becomes more unfavorable as pressure increases. We conclude that a sizeable population of nonpolar side chains remains buried inside a solvent-inaccessible core of the pressure-induced denatured state. At elevated pressures, this core may become packed almost as tightly as the interior of the native state. The presence and partial disappearance of large intraglobular voids is another driving force facilitating pressure-induced denaturation of individual proteins. Our data also have implications for the kinetics of protein folding and shed light on the nature of the folding transition state ensemble." @default.
• W2113991587 created "2016-06-24" @default.
• W2113991587 creator A5041182519 @default.
• W2113991587 creator A5057316262 @default.
• W2113991587 date "2009-12-01" @default.
• W2113991587 modified "2023-10-02" @default.
• W2113991587 title "Origins of Pressure-Induced Protein Transitions" @default.
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• W2113991587 doi "https://doi.org/10.1016/j.jmb.2009.10.020" @default.
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• W2113991587 hasPublicationYear "2009" @default.
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