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• W2113992587 abstract "Objective This study was undertaken to investigate whether amphotericin B vaginal suppositories would be effective in the treatment of non-albicans Candida vaginitis in women who failed conventional therapy. Study design Thirty-two patients were identified with non-albicans Candida vaginitis. These patients were treated with conventional antifungal agents. Ten patients had persistence of the non-albicans Candida infection after treatment. Amphotericin B 50-mg vaginal suppositories were given nightly for 14 days to this subgroup of treatment failures. Results Of 10 women, 8 (80%) who were treated with amphotericin B vaginally initially showed no further infection. One of the treatment successes had 2 recurrences and responded to a second course of amphotericin B but failed a third course. If this patient is considered a treatment failure, then amphotericin B vaginal suppositories were successful in 70% of patients. The medication was well tolerated and local side effects were minimal. Conclusion Amphotericin B vaginal suppositories are a viable treatment option for refractory vaginitis caused by non-albicans Candida. This study was undertaken to investigate whether amphotericin B vaginal suppositories would be effective in the treatment of non-albicans Candida vaginitis in women who failed conventional therapy. Thirty-two patients were identified with non-albicans Candida vaginitis. These patients were treated with conventional antifungal agents. Ten patients had persistence of the non-albicans Candida infection after treatment. Amphotericin B 50-mg vaginal suppositories were given nightly for 14 days to this subgroup of treatment failures. Of 10 women, 8 (80%) who were treated with amphotericin B vaginally initially showed no further infection. One of the treatment successes had 2 recurrences and responded to a second course of amphotericin B but failed a third course. If this patient is considered a treatment failure, then amphotericin B vaginal suppositories were successful in 70% of patients. The medication was well tolerated and local side effects were minimal. Amphotericin B vaginal suppositories are a viable treatment option for refractory vaginitis caused by non-albicans Candida." @default.
• W2113992587 created "2016-06-24" @default.
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• W2113992587 date "2005-06-01" @default.
• W2113992587 modified "2023-10-15" @default.
• W2113992587 title "Treatment of non-albicans Candida vaginitis with amphotericin B vaginal suppositories" @default.
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• W2113992587 doi "https://doi.org/10.1016/j.ajog.2005.03.034" @default.
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