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• W2113992800 abstract "BACKGROUND Several studies have suggested that low 25(OH) vitamin D 3 levels may be prognostic in some malignancies, but no studies have evaluated their impact on treatment outcome in patients with acute myeloid leukemia (AML). METHODS Vitamin D levels were evaluated in 97 consecutive, newly diagnosed, intensively treated patients with AML. MicroRNA expression profiles and single nucleotide polymorphisms (SNPs) in the 25(OH) vitamin D 3 pathway genes were evaluated and correlated with 25(OH) vitamin D 3 levels and treatment outcome. RESULTS Thirty‐four patients (35%) had normal 25(OH) vitamin D 3 levels (32‐100 ng/mL), 34 patients (35%) had insufficient levels (20‐31.9 ng/mL), and 29 patients (30%) had deficient levels (<20 ng/mL). Insufficient/deficient 25(OH) vitamin D 3 levels were associated with worse relapse‐free survival (RFS) compared with normal vitamin D 3 levels. In multivariate analyses, deficient 25(OH) vitamin D 3 , smoking, European Leukemia Network genetic group, and white blood cell count retained their statistical significance for RFS. Several microRNAs and SNPs were associated with 25(OH) vitamin D 3 levels, although none remained significant after multiple test corrections; one 25(OH) vitamin D 3 receptor SNP, rs10783219, was associated with a lower complete remission rate ( P = .0442) and with shorter RFS ( P = .0058) and overall survival ( P = .0011). CONCLUSIONS It remains to be determined what role microRNA and SNP profiles play in contributing to low 25(OH) vitamin D 3 level and/or outcome and whether supplementation will improve outcomes for patients with AML. Cancer 2014;120:521–529 . © 2013 American Cancer Society ." @default.
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• W2113992800 date "2013-10-25" @default.
• W2113992800 modified "2023-10-16" @default.
• W2113992800 title "Low 25(OH) vitamin D₃levels are associated with adverse outcome in newly diagnosed, intensively treated adult acute myeloid leukemia" @default.
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• W2113992800 doi "https://doi.org/10.1002/cncr.28368" @default.
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