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- W2113992931 abstract "Fetal membranes are a primary source of prostaglandins and pro-inflammatory cytokines implicated in human parturition, so the inhibition of inflammatory pathways may be of benefit in pregnancies complicated by premature labour. We have therefore investigated the effects of a cytokine-suppressant anti-inflammatory drug (CSAID) on the output of prostaglandin E(2) (PGE(2)) and interleukin (IL)-1 beta from human fetal membranes in vitro. Bacterial endotoxin increased the expression of mRNA for IL-1 beta and type-2 cyclo-oxygenase (COX-2), and there were corresponding increases in the output of IL-1 beta protein and PGE(2). The CSAID decreased IL-1 beta protein, COX-2 expression and PGE(2) output, but not mRNA for IL-1 beta, indicating a post-translational effect on the production of IL-1 beta and a transcriptional affect on COX-2, with an overall reduction in PGE(2). These findings are consistent with the effects of CSAIDs in other systems, and indicate that they are of possible use in premature labour." @default.
- W2113992931 created "2016-06-24" @default.
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- W2113992931 date "2002-03-01" @default.
- W2113992931 modified "2023-10-18" @default.
- W2113992931 title "The effects of a cytokine suppressive anti-inflammatory drug on the output of prostaglandin E2 and interleukin-1beta from human fetal membranes" @default.
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- W2113992931 doi "https://doi.org/10.1093/molehr/8.3.281" @default.
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