FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113994514> ?p ?o ?g. }

• W2113994514 endingPage "5934" @default.
• W2113994514 startingPage "5927" @default.
• W2113994514 abstract "A novel class of silver N-heterocyclic carbene complexes (5a–f) were synthesized in high yield by reacting silver(I) oxide with 4,5-diarylimidazolium halides (4a–f). The complexes were characterized using NMR and IR spectroscopy. The structure was confirmed on the example of bromo[1,3-diethyl-4,5-bis(4-fluorophenyl)imidazol-2-ylidene]silver(I) (5c) by crystal structure analysis. The X-ray structure indicated a three-dimensional coordination polymer with a repeating unit consisting of a Ccarben-Ag2-Br2-Ccarben cluster. Pharmacological investigations revealed that all silver complexes possessed growth inhibitory effects against breast cancer (MCF-7 and MDA-MB-231) as well as colon carcinoma (HT-29) cells. The most active compound 5c was slightly less active against MCF-7 cells, more active against MDA-MB-231 cells and comparable active as cisplatin against HT-29 cells. Further pharmacological investigations were performed with selected compounds on estrogen receptor (ER) binding, DNA intercalation, cyclooxygenase (COX) inhibition and antibacterial activity. The complexes were only marginally active at the DNA, ER and the COX enzymes, so these targets can be excluded to be involved in the mode of action. However, the growth of bacteria was significantly inhibited by 5c and 5f and opens a new application of this complex type." @default.
• W2113994514 created "2016-06-24" @default.
• W2113994514 creator A5020143743 @default.
• W2113994514 creator A5032467198 @default.
• W2113994514 creator A5050914535 @default.
• W2113994514 creator A5057876555 @default.
• W2113994514 creator A5077280501 @default.
• W2113994514 creator A5077569418 @default.
• W2113994514 creator A5087356091 @default.
• W2113994514 date "2011-12-01" @default.
• W2113994514 modified "2023-10-17" @default.
• W2113994514 title "Synthesis and biological studies of silver N-heterocyclic carbene complexes derived from 4,5-diarylimidazole" @default.
• W2113994514 cites W1965873957 @default.
• W2113994514 cites W1967253297 @default.
• W2113994514 cites W1977587295 @default.
• W2113994514 cites W1982100202 @default.
• W2113994514 cites W2000105510 @default.
• W2113994514 cites W2004345351 @default.
• W2113994514 cites W2005461239 @default.
• W2113994514 cites W2007013745 @default.
• W2113994514 cites W2010321797 @default.
• W2113994514 cites W2013560358 @default.
• W2113994514 cites W2016154684 @default.
• W2113994514 cites W2017356685 @default.
• W2113994514 cites W2021662089 @default.
• W2113994514 cites W2030140882 @default.
• W2113994514 cites W2034023714 @default.
• W2113994514 cites W2046097532 @default.
• W2113994514 cites W2048680922 @default.
• W2113994514 cites W2050762893 @default.
• W2113994514 cites W2062116598 @default.
• W2113994514 cites W2066977665 @default.
• W2113994514 cites W2076815064 @default.
• W2113994514 cites W2078198776 @default.
• W2113994514 cites W2082047617 @default.
• W2113994514 cites W2085388752 @default.
• W2113994514 cites W2093345655 @default.
• W2113994514 cites W2118749301 @default.
• W2113994514 cites W2133142785 @default.
• W2113994514 cites W2138313740 @default.
• W2113994514 cites W2140777434 @default.
• W2113994514 cites W2329884821 @default.
• W2113994514 cites W4211213857 @default.
• W2113994514 doi "https://doi.org/10.1016/j.ejmech.2011.10.002" @default.
• W2113994514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22019187" @default.
• W2113994514 hasPublicationYear "2011" @default.
• W2113994514 type Work @default.
• W2113994514 sameAs 2113994514 @default.
• W2113994514 citedByCount "54" @default.
• W2113994514 countsByYear W21139945142012 @default.
• W2113994514 countsByYear W21139945142013 @default.
• W2113994514 countsByYear W21139945142014 @default.
• W2113994514 countsByYear W21139945142015 @default.
• W2113994514 countsByYear W21139945142016 @default.
• W2113994514 countsByYear W21139945142017 @default.
• W2113994514 countsByYear W21139945142018 @default.
• W2113994514 countsByYear W21139945142019 @default.
• W2113994514 countsByYear W21139945142020 @default.
• W2113994514 countsByYear W21139945142021 @default.
• W2113994514 countsByYear W21139945142022 @default.
• W2113994514 countsByYear W21139945142023 @default.
• W2113994514 crossrefType "journal-article" @default.
• W2113994514 hasAuthorship W2113994514A5020143743 @default.
• W2113994514 hasAuthorship W2113994514A5032467198 @default.
• W2113994514 hasAuthorship W2113994514A5050914535 @default.
• W2113994514 hasAuthorship W2113994514A5057876555 @default.
• W2113994514 hasAuthorship W2113994514A5077280501 @default.
• W2113994514 hasAuthorship W2113994514A5077569418 @default.
• W2113994514 hasAuthorship W2113994514A5087356091 @default.
• W2113994514 hasConcept C116073593 @default.
• W2113994514 hasConcept C137824038 @default.
• W2113994514 hasConcept C161790260 @default.
• W2113994514 hasConcept C178790620 @default.
• W2113994514 hasConcept C181199279 @default.
• W2113994514 hasConcept C185592680 @default.
• W2113994514 hasConcept C202751555 @default.
• W2113994514 hasConcept C2777164566 @default.
• W2113994514 hasConcept C41183919 @default.
• W2113994514 hasConcept C55493867 @default.
• W2113994514 hasConcept C71240020 @default.
• W2113994514 hasConceptScore W2113994514C116073593 @default.
• W2113994514 hasConceptScore W2113994514C137824038 @default.
• W2113994514 hasConceptScore W2113994514C161790260 @default.
• W2113994514 hasConceptScore W2113994514C178790620 @default.
• W2113994514 hasConceptScore W2113994514C181199279 @default.
• W2113994514 hasConceptScore W2113994514C185592680 @default.
• W2113994514 hasConceptScore W2113994514C202751555 @default.
• W2113994514 hasConceptScore W2113994514C2777164566 @default.
• W2113994514 hasConceptScore W2113994514C41183919 @default.
• W2113994514 hasConceptScore W2113994514C55493867 @default.
• W2113994514 hasConceptScore W2113994514C71240020 @default.
• W2113994514 hasIssue "12" @default.
• W2113994514 hasLocation W21139945141 @default.
• W2113994514 hasLocation W21139945142 @default.
• W2113994514 hasOpenAccess W2113994514 @default.
• W2113994514 hasPrimaryLocation W21139945141 @default.
• W2113994514 hasRelatedWork W1990749895 @default.
• W2113994514 hasRelatedWork W2022671731 @default.

• next