FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113995872> ?p ?o ?g. }

• W2113995872 abstract "Summary Some progress has been made regarding availability of recombinant factor VIII concentrates and prophylaxis for haemophilia A in emerging countries, where plasma‐derived concentrates were used in the vast majority. Clinical studies to document their introduction and effectiveness are so far not widely available in literature. This non‐interventional study evaluates the real‐life effectiveness and safety of prophylactic and on‐demand treatment with recombinant factor VIII formulated with sucrose ( rFVIII‐FS ) for bleed control and preservation of joints in emerging countries from Eastern Europe, North Africa and Middle East area. One hundred and eighty‐six patients from 11 countries were enrolled, mean ± SD age 12.8 ± 12.7 years. At enrolment, majority (79.6%) had severe haemophilia A (<2% IU mL −1 ), 47.8% had a target joint, 15% had an inhibitor history and one patient was on immune tolerance induction. During the 24‐month observation period, 58.1% of the patients were prescribed prophylaxis at every visit, 31.7% were on an on‐demand regimen. Patients with severe haemophilia A on prophylaxis ( n = 82) had a mean annual rate of treated bleeds of 2.8 ± 4.4, whereas it was 19.1 ± 32.0 for the on‐demand group ( n = 31), and a mean total Gilbert Score of 9.9 ± 10.3 at baseline and 4.1 ± 6.7 at study end; vs. 15.2 ± 17.3 and 13.7 ± 17.1 for on‐demand respectively. The majority of the bleeds (91.1%) were treated with one or two infusions. Four patients without inhibitor history had a first positive inhibitor test during the study. This study demonstrates the effective use of rFVIII ‐ FS in emerging countries and adds to the established safety profile of rFVIII ‐FS." @default.
• W2113995872 created "2016-06-24" @default.
• W2113995872 creator A5001276485 @default.
• W2113995872 creator A5019005271 @default.
• W2113995872 creator A5019341062 @default.
• W2113995872 creator A5030653981 @default.
• W2113995872 creator A5041524087 @default.
• W2113995872 creator A5056998708 @default.
• W2113995872 creator A5076987284 @default.
• W2113995872 creator A5089343993 @default.
• W2113995872 creator A5033295167 @default.
• W2113995872 date "2015-02-04" @default.
• W2113995872 modified "2023-09-27" @default.
• W2113995872 title "Real‐life evidence in evaluating effectiveness of treatment in Haemophilia A with a recombinant FVIII concentrate: A non‐interventional study in emerging countries" @default.
• W2113995872 cites W1566919421 @default.
• W2113995872 cites W1722143763 @default.
• W2113995872 cites W1754890660 @default.
• W2113995872 cites W1890969760 @default.
• W2113995872 cites W1963967196 @default.
• W2113995872 cites W1972885829 @default.
• W2113995872 cites W1979670895 @default.
• W2113995872 cites W1986750705 @default.
• W2113995872 cites W1997223335 @default.
• W2113995872 cites W2005662779 @default.
• W2113995872 cites W2006013990 @default.
• W2113995872 cites W2013607072 @default.
• W2113995872 cites W2018429989 @default.
• W2113995872 cites W2020123164 @default.
• W2113995872 cites W2025981541 @default.
• W2113995872 cites W2033552708 @default.
• W2113995872 cites W2034317941 @default.
• W2113995872 cites W2039215350 @default.
• W2113995872 cites W2042338172 @default.
• W2113995872 cites W2046494127 @default.
• W2113995872 cites W2062677551 @default.
• W2113995872 cites W2064194152 @default.
• W2113995872 cites W2064216283 @default.
• W2113995872 cites W2064386996 @default.
• W2113995872 cites W2082192168 @default.
• W2113995872 cites W2085752173 @default.
• W2113995872 cites W2093390545 @default.
• W2113995872 cites W2104946758 @default.
• W2113995872 cites W2109130849 @default.
• W2113995872 cites W2111507766 @default.
• W2113995872 cites W2111802082 @default.
• W2113995872 cites W2139220283 @default.
• W2113995872 cites W2143958714 @default.
• W2113995872 cites W2149564822 @default.
• W2113995872 cites W2167801052 @default.
• W2113995872 cites W3028168461 @default.
• W2113995872 cites W4256094455 @default.
• W2113995872 doi "https://doi.org/10.1111/hae.12631" @default.
• W2113995872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25649665" @default.
• W2113995872 hasPublicationYear "2015" @default.
• W2113995872 type Work @default.
• W2113995872 sameAs 2113995872 @default.
• W2113995872 citedByCount "7" @default.
• W2113995872 countsByYear W21139958722016 @default.
• W2113995872 countsByYear W21139958722018 @default.
• W2113995872 countsByYear W21139958722020 @default.
• W2113995872 crossrefType "journal-article" @default.
• W2113995872 hasAuthorship W2113995872A5001276485 @default.
• W2113995872 hasAuthorship W2113995872A5019005271 @default.
• W2113995872 hasAuthorship W2113995872A5019341062 @default.
• W2113995872 hasAuthorship W2113995872A5030653981 @default.
• W2113995872 hasAuthorship W2113995872A5033295167 @default.
• W2113995872 hasAuthorship W2113995872A5041524087 @default.
• W2113995872 hasAuthorship W2113995872A5056998708 @default.
• W2113995872 hasAuthorship W2113995872A5076987284 @default.
• W2113995872 hasAuthorship W2113995872A5089343993 @default.
• W2113995872 hasConcept C126322002 @default.
• W2113995872 hasConcept C141071460 @default.
• W2113995872 hasConcept C187212893 @default.
• W2113995872 hasConcept C197934379 @default.
• W2113995872 hasConcept C2776259030 @default.
• W2113995872 hasConcept C2777232031 @default.
• W2113995872 hasConcept C2778385053 @default.
• W2113995872 hasConcept C2781413609 @default.
• W2113995872 hasConcept C71924100 @default.
• W2113995872 hasConceptScore W2113995872C126322002 @default.
• W2113995872 hasConceptScore W2113995872C141071460 @default.
• W2113995872 hasConceptScore W2113995872C187212893 @default.
• W2113995872 hasConceptScore W2113995872C197934379 @default.
• W2113995872 hasConceptScore W2113995872C2776259030 @default.
• W2113995872 hasConceptScore W2113995872C2777232031 @default.
• W2113995872 hasConceptScore W2113995872C2778385053 @default.
• W2113995872 hasConceptScore W2113995872C2781413609 @default.
• W2113995872 hasConceptScore W2113995872C71924100 @default.
• W2113995872 hasFunder F4320320303 @default.
• W2113995872 hasIssue "3" @default.
• W2113995872 hasLocation W21139958721 @default.
• W2113995872 hasLocation W21139958722 @default.
• W2113995872 hasOpenAccess W2113995872 @default.
• W2113995872 hasPrimaryLocation W21139958721 @default.
• W2113995872 hasRelatedWork W1492650379 @default.
• W2113995872 hasRelatedWork W1550865219 @default.
• W2113995872 hasRelatedWork W1969419914 @default.
• W2113995872 hasRelatedWork W2067082011 @default.
• W2113995872 hasRelatedWork W2111744314 @default.
• W2113995872 hasRelatedWork W2418682518 @default.

• next