FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113995940> ?p ?o ?g. }

• W2113995940 endingPage "50" @default.
• W2113995940 startingPage "50" @default.
• W2113995940 abstract "Sir, Marjolin ulcer is the term commonly used to describe squamous cell carcinoma (SCC) arising on scar tissue. It is a malignant transformation of a chronic ulcer, sinus tract, fistula or long-standing scar of various etiologies. Jame Nicholas Marjolin in 1828 published the classical description of Marjolin's ulcer. The most frequent malignancy that develops in burns scars is squamous in type.[1] Melanoma, schwannoma, sarcoma, trichilemmal carcinoma have also been described.[2] Limbs are the common site for Marjolin's ulcer. Two different clinical presentations are common ulcerative form and less frequent, exophytic papillary form.[3] We report a case of a 58-year-old lady who developed ulcerative and exophytic mass from a 10 year old burns scar over the back She reported with discomfort over the back to the family physician who found and ulcer over the scar and suspected malignancy. Within four months, the ulcer rapidly progressed to a cauliflower-shaped growth. She was not a diabetic or hypertensive. There was no family history of malignancy. On examination, there was a large exophytic ulcerated growth and a small superficial ulcer arising from a large depigmented atrophic scar over the back [Figure 1]. There was no lymphadenopathy. The other skin and mucosal sites appeared normal. Relevant investigations were normal. Histopathology showed a well-differentiated SCC with horn pearls [Figure 2]. She was advised radiation therapy.Figure 1: An exophytic ulcerated growth and a small superficial ulcer with intervening erosion over a large depigmented atrophic scarFigure 2: Histopathology H and E, ×400 showing well-differentiated squamous cell carcinoma with horn pearlsThe exact pathogenesis of Marjolin's ulcer remains unclear. Theories suggest that cellular mutations as a result of toxins released by damaged, ischaemic and nutritionally deficient tissues are responsible for neoplastic change, with a locally impaired immune function contributing as trigger. Persistence of burns ulcer, induration or elevation of margin of such ulcer, ulceration or nodule formation over a burns scar may indicate malignant transformation. The latent period is shorter in elderly and in cases of basal cell epithelioma. Metastasis among squamous carcinomas following a burns scar is much more common than among those associated with actinic damage.[4] Punch biopsy should be avoided, due to the focal nature of the malignant changes in burn scar.[5] In our case, the spine region being more prone for pressure-induced damage, the resultant necrosis could have initiated the malignant process. This case is reported the rarity of occurrence of Marjolin's ulcer over the back, presenting as both ulcerative and exophytic growth. Even a small abrasion over a long standing burns scar should be viewed with suspicion. All burn scars should be grafted as the incidence of carcinoma is reduced if such wounds are grafted at an early stage. ACKNOWLEDGMENT We acknowledge the Department of Pathology, Thanjavur Medical College for facilitating in getting the histology slide." @default.
• W2113995940 created "2016-06-24" @default.
• W2113995940 creator A5025599858 @default.
• W2113995940 creator A5031518546 @default.
• W2113995940 creator A5063840125 @default.
• W2113995940 creator A5077645490 @default.
• W2113995940 creator A5084973502 @default.
• W2113995940 date "2014-01-01" @default.
• W2113995940 modified "2023-09-26" @default.
• W2113995940 title "Marjolin′s ulcer: A rare report" @default.
• W2113995940 cites W1516766006 @default.
• W2113995940 cites W1582037260 @default.
• W2113995940 cites W1994688547 @default.
• W2113995940 cites W2094729807 @default.
• W2113995940 doi "https://doi.org/10.4103/2229-5178.144534" @default.
• W2113995940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4252953" @default.
• W2113995940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25506566" @default.
• W2113995940 hasPublicationYear "2014" @default.
• W2113995940 type Work @default.
• W2113995940 sameAs 2113995940 @default.
• W2113995940 citedByCount "0" @default.
• W2113995940 crossrefType "journal-article" @default.
• W2113995940 hasAuthorship W2113995940A5025599858 @default.
• W2113995940 hasAuthorship W2113995940A5031518546 @default.
• W2113995940 hasAuthorship W2113995940A5063840125 @default.
• W2113995940 hasAuthorship W2113995940A5077645490 @default.
• W2113995940 hasAuthorship W2113995940A5084973502 @default.
• W2113995940 hasBestOaLocation W21139959401 @default.
• W2113995940 hasConcept C141071460 @default.
• W2113995940 hasConcept C142724271 @default.
• W2113995940 hasConcept C16005928 @default.
• W2113995940 hasConcept C2777642821 @default.
• W2113995940 hasConcept C2779399171 @default.
• W2113995940 hasConcept C544855455 @default.
• W2113995940 hasConcept C71924100 @default.
• W2113995940 hasConceptScore W2113995940C141071460 @default.
• W2113995940 hasConceptScore W2113995940C142724271 @default.
• W2113995940 hasConceptScore W2113995940C16005928 @default.
• W2113995940 hasConceptScore W2113995940C2777642821 @default.
• W2113995940 hasConceptScore W2113995940C2779399171 @default.
• W2113995940 hasConceptScore W2113995940C544855455 @default.
• W2113995940 hasConceptScore W2113995940C71924100 @default.
• W2113995940 hasIssue "5" @default.
• W2113995940 hasLocation W21139959401 @default.
• W2113995940 hasLocation W21139959402 @default.
• W2113995940 hasLocation W21139959403 @default.
• W2113995940 hasLocation W21139959404 @default.
• W2113995940 hasLocation W21139959405 @default.
• W2113995940 hasOpenAccess W2113995940 @default.
• W2113995940 hasPrimaryLocation W21139959401 @default.
• W2113995940 hasRelatedWork W1972372609 @default.
• W2113995940 hasRelatedWork W1997881595 @default.
• W2113995940 hasRelatedWork W2002120878 @default.
• W2113995940 hasRelatedWork W2003938723 @default.
• W2113995940 hasRelatedWork W2011177479 @default.
• W2113995940 hasRelatedWork W2046890127 @default.
• W2113995940 hasRelatedWork W2047967234 @default.
• W2113995940 hasRelatedWork W2118496982 @default.
• W2113995940 hasRelatedWork W2399694880 @default.
• W2113995940 hasRelatedWork W2439875401 @default.
• W2113995940 hasVolume "5" @default.
• W2113995940 isParatext "false" @default.
• W2113995940 isRetracted "false" @default.
• W2113995940 magId "2113995940" @default.
• W2113995940 workType "article" @default.