Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113996510> ?p ?o ?g. }
- W2113996510 endingPage "1191" @default.
- W2113996510 startingPage "1181" @default.
- W2113996510 abstract "B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly diversified endogenous immunoglobulin and present clonally unique variable-region idiotypic (Id) peptides on their major histocompatibility complex (MHC) class II molecules to Id-specific T cells. We show that B cells chronically helped by Id-specific Th2 cells developed into large B cell lymphomas with cytogenetic DNA aberrations. The lymphomas expressed high amounts of Id, MHC class II, CD80/86, and CD40 and bidirectionally collaborated with Th2 cells. Thus, MHC class II–presented Id peptides may represent a chronic self-antigenic stimulus for T cell–dependent lymphomagenesis. Eventually, B lymphomas grew independent of T cells. Thus, T cells do not only eliminate cancers as currently believed. In fact, Id-specific Th2 cells can induce B lymphomas." @default.
- W2113996510 created "2016-06-24" @default.
- W2113996510 creator A5000560776 @default.
- W2113996510 creator A5005876566 @default.
- W2113996510 creator A5008099364 @default.
- W2113996510 creator A5009481797 @default.
- W2113996510 creator A5058258046 @default.
- W2113996510 creator A5066688965 @default.
- W2113996510 creator A5070289679 @default.
- W2113996510 creator A5083802834 @default.
- W2113996510 date "2007-05-07" @default.
- W2113996510 modified "2023-10-02" @default.
- W2113996510 title "Lymphomas can develop from B cells chronically helped by idiotype-specific T cells" @default.
- W2113996510 cites W1488337004 @default.
- W2113996510 cites W1495792176 @default.
- W2113996510 cites W1526178344 @default.
- W2113996510 cites W1583001054 @default.
- W2113996510 cites W1583116384 @default.
- W2113996510 cites W1669655813 @default.
- W2113996510 cites W1931685135 @default.
- W2113996510 cites W1947079675 @default.
- W2113996510 cites W1966670960 @default.
- W2113996510 cites W1980448977 @default.
- W2113996510 cites W1983489425 @default.
- W2113996510 cites W1989719910 @default.
- W2113996510 cites W1993029819 @default.
- W2113996510 cites W1995129175 @default.
- W2113996510 cites W2000824376 @default.
- W2113996510 cites W2011995348 @default.
- W2113996510 cites W2013856810 @default.
- W2113996510 cites W2021171466 @default.
- W2113996510 cites W2025412364 @default.
- W2113996510 cites W2026496528 @default.
- W2113996510 cites W2031026925 @default.
- W2113996510 cites W2035916624 @default.
- W2113996510 cites W2036207368 @default.
- W2113996510 cites W2039358472 @default.
- W2113996510 cites W2042627347 @default.
- W2113996510 cites W2044291825 @default.
- W2113996510 cites W2050161362 @default.
- W2113996510 cites W2050657939 @default.
- W2113996510 cites W2054546042 @default.
- W2113996510 cites W2064224707 @default.
- W2113996510 cites W2069634988 @default.
- W2113996510 cites W2072719177 @default.
- W2113996510 cites W2077260509 @default.
- W2113996510 cites W2086097433 @default.
- W2113996510 cites W2097948293 @default.
- W2113996510 cites W2106792404 @default.
- W2113996510 cites W2109579779 @default.
- W2113996510 cites W2111344966 @default.
- W2113996510 cites W2112346826 @default.
- W2113996510 cites W2116167482 @default.
- W2113996510 cites W2117971688 @default.
- W2113996510 cites W2119005151 @default.
- W2113996510 cites W2121626779 @default.
- W2113996510 cites W2132598458 @default.
- W2113996510 cites W2133762985 @default.
- W2113996510 cites W2138139298 @default.
- W2113996510 cites W2142294608 @default.
- W2113996510 cites W2143500395 @default.
- W2113996510 cites W2150382709 @default.
- W2113996510 cites W2152065787 @default.
- W2113996510 cites W2153844761 @default.
- W2113996510 cites W2155688181 @default.
- W2113996510 cites W2169180623 @default.
- W2113996510 cites W2416155065 @default.
- W2113996510 cites W2560367415 @default.
- W2113996510 cites W305784451 @default.
- W2113996510 cites W334013582 @default.
- W2113996510 doi "https://doi.org/10.1084/jem.20061220" @default.
- W2113996510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2118585" @default.
- W2113996510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17485509" @default.
- W2113996510 hasPublicationYear "2007" @default.
- W2113996510 type Work @default.
- W2113996510 sameAs 2113996510 @default.
- W2113996510 citedByCount "44" @default.
- W2113996510 countsByYear W21139965102012 @default.
- W2113996510 countsByYear W21139965102013 @default.
- W2113996510 countsByYear W21139965102014 @default.
- W2113996510 countsByYear W21139965102015 @default.
- W2113996510 countsByYear W21139965102017 @default.
- W2113996510 countsByYear W21139965102018 @default.
- W2113996510 countsByYear W21139965102019 @default.
- W2113996510 countsByYear W21139965102022 @default.
- W2113996510 countsByYear W21139965102023 @default.
- W2113996510 crossrefType "journal-article" @default.
- W2113996510 hasAuthorship W2113996510A5000560776 @default.
- W2113996510 hasAuthorship W2113996510A5005876566 @default.
- W2113996510 hasAuthorship W2113996510A5008099364 @default.
- W2113996510 hasAuthorship W2113996510A5009481797 @default.
- W2113996510 hasAuthorship W2113996510A5058258046 @default.
- W2113996510 hasAuthorship W2113996510A5066688965 @default.
- W2113996510 hasAuthorship W2113996510A5070289679 @default.
- W2113996510 hasAuthorship W2113996510A5083802834 @default.
- W2113996510 hasBestOaLocation W21139965101 @default.
- W2113996510 hasConcept C147483822 @default.
- W2113996510 hasConcept C153911025 @default.