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• W2113996523 abstract "<h3>Abstract</h3> Phytosphingosine (PHS) is a naturally occurring bioactive sphingolipid molecule. Intermediates such as sphingolipid long-chain bases (LCBs) in sphingolipid biosynthesis have been shown to have important roles as signaling molecules. In this study, exogenous addition of PHS caused rapid induction of transcripts responsible for transient synthesis of LCBs, reactive oxygen species, and ethylene. These events were followed by the induction of sphingolipid kinase (SphK), which metabolized PHS to phytosphingosine-1-phosphate in an biphasic manner. PHS alleviated not only pathogen-induced cell damage but also reduced the growth of virulent pathogens in the entire upper part of the PHS-treated plant stem during the necrotic stage after inoculation, suggesting the development of systemic acquired resistance (SAR) and plant immunity. Moreover, PHS treatment up-regulated the transcription and activity of SphK, accompanied by prominent increases in the transcription levels of serine palmitoyltransferase (<i>LCB1</i> and <i>LCB2</i>) for <i>de novo</i> synthesis of sphingolipids, as well as ROS-detoxifying enzymes and PR proteins at 48 h after virulent pathogen infection. The impairment of ROS production at this time is more beneficial for the activation of SphK and inhibition of pathogenicity during the necrotic stage of hemibiotrophic infection, indicating that necrotic cell death at the late stage is regulated by ROS-independent SphK. Phosphorylated LCBs significantly reduced pathogen-induced cell damage. These observations suggest that selective channeling of sphingolipids into phosphorylated forms in a time-dependent manner has a pro-survival effect by promoting SAR in plant immunity. 4.<h3>One Sentence Summary</h3> Selective gene expression in sphingolipid biosynthesis and channeling into their phosphorylated forms are significant determinants of their roles as pro-survival signaling molecules." @default.
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• W2113996523 date "2011-09-13" @default.
• W2113996523 modified "2023-10-18" @default.
• W2113996523 title "Right ventriculo-arterial coupling in pulmonary hypertension: a magnetic resonance study" @default.
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• W2113996523 doi "https://doi.org/10.1136/heartjnl-2011-300462" @default.
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