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• W2113996618 abstract "<b>Background:</b> A reliable challenge model is needed to evaluate <i>Helicobacter pylori</i> vaccine candidates. <b>Methods:</b> A <i>cag</i> pathogenicity island negative, OipA positive, multiple antibiotic susceptible strain of <i>H pylori</i> obtained from an individual with mild gastritis (Baylor strain 100) was used to challenge volunteers. Volunteers received 40 mg of famotidine at bedtime and 10⁴–10¹⁰ cfu of <i>H pylori</i> in beef broth the next morning. Infection was confirmed by ¹³C urea breath test (¹³C-UBT), culture, and histology. Eradication therapy was given four or 12 weeks post challenge and eradication was confirmed by at least two separate UBTs, as well as culture and histology. <b>Results:</b> Twenty subjects (nine women and 11 men; aged 23–33 years) received a <i>H pylori</i> challenge. Eighteen (90%) became infected. Mild to moderate dyspeptic symptoms occurred, peaked between days 9 and 12, and resolved. Vomitus from one subject contained >10³ viable/ml <i>H pylori</i>. By two weeks post challenge gastric histology showed typical chronic <i>H pylori</i> gastritis with intense acute and chronic inflammation. The density of <i>H pylori</i> (as assessed by cfu/biopsy) was similarly independent of the challenge dose. A minimal infectious dose was not found. Gastric mucosal interleukin 8 levels increased more than 20-fold by two weeks after the challenge. <b>Conclusion:</b> Challenge reliably resulted in <i>H pylori</i> infection. Infection was associated with typical <i>H pylori</i> gastritis with intense polymorphonuclear cell infiltration and interleukin 8 induction in gastric mucosa, despite absence of the <i>cag</i> pathogenicity island. Experimental <i>H pylori</i> infection is one of the viable approaches to evaluate vaccine candidates." @default.
• W2113996618 created "2016-06-24" @default.
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• W2113996618 date "2004-09-01" @default.
• W2113996618 modified "2023-09-26" @default.
• W2113996618 title "Challenge model for Helicobacter pylori infection in human volunteers" @default.
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• W2113996618 doi "https://doi.org/10.1136/gut.2003.037499" @default.
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